This study is looking at whether tadalafil, a medication, can help reduce shortness of breath (dyspnea) in 126 Veterans who have Chronic Obstructive Pulmonary Disease (COPD) and high blood pressure in their lungs (Pulmonary Hypertension). You would take either tadalafil or an inactive identical capsule (placebo) once a day. Neither you nor the study team would know which one you are taking. Researchers will measure your shortness of breath after 6 months to see if tadalafil helps. They will also look at your quality of life, daily activity, exercise ability, and lung function. The study is currently recruiting participants aged 35 to 89 years old.

Study design

This is an interventional study involving 126 participants. Participants will be randomly assigned to receive either tadalafil or a placebo, and neither they nor the researchers will know which treatment they are receiving.

What's involved

You would take one or two encapsulated tablets of tadalafil or placebo by mouth once daily. You would have clinic or telephone follow-up visits at 1, 2, 3, 4, 5, and 6 months.

Compensation

Not stated in the trial record.

Follow-up

Your shortness of breath will be measured at 6 months, and you will be followed closely for safety during this time.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.