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Cerebellar TMS and Satiety in Prader-Willi Syndrome

This study is looking at how a non-invasive (no surgery) brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) might help with hyperphagia (extreme hunger) and satiety (feeling full) in people with Prader-Willi syndrome. rTMS uses a magnetic field to gently change brain activity. Researchers want to understand if stimulating a specific part of the brain can improve these symptoms. You may be able to join if you are 18-64 years old, have Prader-Willi syndrome, and do not have certain medical conditions like a history of seizures or metal in your body. The study aims to enroll 20 participants, and its current recruitment status is unclear.

Study design
This interventional study plans to enroll 20 participants to learn more about rTMS for Prader-Willi syndrome.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will have a follow-up visit one week after receiving rTMS.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05938543

Cerebellar TMS and Satiety in Prader-Willi Syndrome

Recruiting
NAAges 18–64InterventionalBasic science
Brigham and Women's Hospital
~20 participants
Updated 2025-12-05 on ClinicalTrials.gov
What's tested:Repetitive Transcranial Magnetic Stimulation (rTMS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Retention of subjects in study assessments
Measured over 1-week post-TMS follow-up visit
+2 more outcomes measured

Conditions

Prader-Willi Syndrome

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Prader-Willi Syndrome

NCT05938543

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • McLean Hospital

    Belmont, Massachusettsstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Laura Holsen, PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

Who to contact

Laura Holsen, PhD
[email protected]
617-525-8772
Email the study team

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Eligibility criteria

Inclusion

Diagnosis of Prader-Willi syndrome

Exclusion

contraindications for TMS or MRI including :
history of neurological disorder
history of head trauma resulting in loss of consciousness
history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy
metal in brain or skull
implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt claustrophobic in MRI

What this trial measures

  • Retention of subjects in study assessments1-week post-TMS follow-up visit

    Retention of subjects for assessments at baseline and 1-week post-TMS follow-up visit, as measured by the percentage (%) of enrolled subjects who complete baseline assessments and then go on to complete the 1-week post-TMS follow-up visit.

  • Time required to enroll subjects into studyAt study completion, up to 18 months

    Time required to enroll the target sample size (n=12) into the study

  • Change in BOLD responsebaseline, 1-week post-TMS follow-up visit

    Change in functional activation of the cerebellum and ventral striatum will be assessed before (baseline) and after TMS stimulation (1-week post-TMS follow-up visit)