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Understanding Microvascular Dysfunction After Gestational Diabetes

This study is looking into why women who have had gestational diabetes (diabetes during pregnancy) might have problems with their small blood vessels (microvascular dysfunction) later on. Researchers will use a minimally invasive technique on a small area of skin to see how your blood vessels react to two different substances: acetylcholine and insulin aspart. They want to understand if oxidative stress (an imbalance in the body that can damage cells) plays a role. The main goal is to measure how well your small blood vessels widen in response to acetylcholine and insulin aspart. This study plans to include 28 women, aged 18-50, who have either had gestational diabetes within the last five years or have no history of it. The study is currently unclear on its recruitment status.

Study design
This is an interventional study planning to enroll 28 women. It is not specified if it is randomized or blinded.
What's involved
You would participate in a single study visit lasting about 4 hours, during which substances will be applied to a small area of your skin.
Compensation
Not stated in the trial record.
Follow-up
Your microvascular dilation will be measured at the study visit, which lasts about 4 hours. No further follow-up is specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05946785

Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes

Recruiting
EARLY_PHASE1Ages 18–50InterventionalBasic science
Anna Stanhewicz, PhD
~28 participants
Updated 2026-07-29 on ClinicalTrials.gov
What's tested:Acetylcholineinsulin aspart

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
microvascular acetylcholine-mediated dilation
Measured over at the study visit, an average of 4 hours
+1 more outcome measured

Conditions

Gestational Diabetes
Vascular Endothelial Function

Explore related trials

Gestational Diabetes

Where it's being run

1 sites across 1 states
Iowa1

Who to contact

Anna Reid-Stanhewicz, PHD
[email protected]
319-467-1732
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

female sex
18 -50 years old
pregnancy history within 5 years of the study visit
had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes
or without a history of gestational diabetes

Exclusion

skin diseases
current tobacco/e-cigarette use
diagnosed or suspected hepatic or metabolic disease including diabetes
statin or other cholesterol-lowering medication
current antihypertensive medication
history of preeclampsia or gestational hypertension
current pregnancy
body mass index \<18.5 kg/m2
allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs.

What this trial measures

  • microvascular acetylcholine-mediated dilationat the study visit, an average of 4 hours

    cutaneous vascular vasodilator responses to acetylcholine perfusion in lactated Ringer's, ascorbate, and L-NAME treated microdialysis sites

  • microvascular insulin-mediated dilationat the study visit, an average of 4 hours

    cutaneous vascular vasodilator responses to insulin perfusion in lactated Ringer's, ascorbate, and L-NAME treated microdialysis sites