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NCT05947305

Alternative Gingival De-Epithelialization Techniques

Enrolling by Invitation
NAAges 18+InterventionalTreatment
University of Michigan
~48 participants
Updated 2026-01-16 on ClinicalTrials.gov
What's tested:Surgical BladeMucotomeDiamond BurEr:YAG Laser

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Histomorphometric Comparison
Measured over After Day 0 (Baseline surgery)

Conditions

Recession, Gingival
Surgical Procedure, Unspecified
Graft Complication
Wound Heal

Explore related trials

Gingival Recession

Where it's being run

1 sites across 1 states
Michigan1

Study leadership

  • Sandra Stuhr, DMD, MS · PRINCIPAL_INVESTIGATOR · University of Michigan

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

American Society of Anesthesiologists (ASA) Physical Status Classification I or II
Subjects undergoing periodontal surgical procedures that involve harvesting of soft tissue samples, who have a treatment plan including the use or removal of keratinized mucosa or subepithelial connective tissue that will not require additional anesthesia for sample collection
Adequate physical and mental health to undergo routine dental treatment
Ability and willingness to follow instructions related to the study procedures

Exclusion

Poorly controlled diabetes, defined as HbA1c \>/= 7.0
Autoimmune or inflammatory conditions such as systemic lupus erythematous, rheumatoid arthritis.
Pregnant women or nursing mothers, or unsure of pregnancy status (self-reported)
Severe hematologic disorders, such as leukemia or hemophilia
Subjects on anticoagulant or antiplatelet therapy
Local or systemic infection that may interfere with healing
Hepatic or renal diseases
Currently under cancer treatment or within 18 months from completion of radio- or chemotherapy
History of antibiotic or immunosuppressant use in the last 3 months
Subjects on concomitant drug therapy for systemic conditions that may affect outcomes of the study
Current smokers (CDC definition): heavy smokers: subjects who have smoked \>10 cigarettes per day within 6 months of study onset, and have smoked \>100 cigarettes in their lifetime

What this trial measures

  • Histomorphometric ComparisonAfter Day 0 (Baseline surgery)

    Histomorphometric evaluation of the relative proportion of epithelial tissue remnants (percentage) after de-epithelialization of the CTG