Phase 1 Study of 99mTc-p5+14 for Systemic Amyloidosis

This study is testing a new imaging agent called 99mTc-p5+14. This agent is designed to help doctors see amyloid deposits in your body, especially in the heart, using special scans (like SPECT/CT). Amyloidosis is a condition where abnormal proteins called amyloid build up in organs. Researchers want to see how 99mTc-p5+14 moves through the body in healthy volunteers and in people with AL or ATTR systemic amyloidosis. They will also compare it to another imaging agent, 99mTc-Pyrophosphate, which is already used to diagnose heart-related ATTR amyloidosis. The main goal is to understand how much radiation exposure you would receive from 99mTc-p5+14. This study is looking for up to 31 participants, including adults aged 18 and older. The current status of the study is unclear.

Study design
This is an interventional study involving up to 31 participants. It will include both healthy volunteers and patients with systemic amyloidosis.
What's involved
The study involves measurements of radiation exposure from enrollment to 8 days after the start of the study.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 8 days after enrollment to measure whole body effective dosimetry.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05951816

A Phase 1 Study of 99mTc-p5+14 in Healthy Volunteers and Patients With AL or ATTR Systemic Amyloidosis

Recruiting
PHASE1Ages 18+InterventionalDiagnostic
University of Tennessee Graduate School of Medicine
~31 participants
Updated 2026-07-24 on ClinicalTrials.gov
What's tested:99mTc-p5+14 is an amyloid reactive peptide labeled with technetium-99m.99mTc-Pyrophosphate

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Whole body effective dosimetry measurement
Measured over From enrollment to the end of study is 8 days
Systemic Amyloidosis
1 sites across 1 states
Tennessee1
  • Jonathan S Wall, PhD · PRINCIPAL_INVESTIGATOR · University of Tennessee Graduate School of Medicine

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  • Whole body effective dosimetry measurementFrom enrollment to the end of study is 8 days

    Whole body effective radiation dose assessed from analysis of organ-specific radioactivity uptake in planar and SPECT images.