Phase 1 Study of 99mTc-p5+14 for Systemic Amyloidosis
This study is testing a new imaging agent called 99mTc-p5+14. This agent is designed to help doctors see amyloid deposits in your body, especially in the heart, using special scans (like SPECT/CT). Amyloidosis is a condition where abnormal proteins called amyloid build up in organs. Researchers want to see how 99mTc-p5+14 moves through the body in healthy volunteers and in people with AL or ATTR systemic amyloidosis. They will also compare it to another imaging agent, 99mTc-Pyrophosphate, which is already used to diagnose heart-related ATTR amyloidosis. The main goal is to understand how much radiation exposure you would receive from 99mTc-p5+14. This study is looking for up to 31 participants, including adults aged 18 and older. The current status of the study is unclear.
- Study design
- This is an interventional study involving up to 31 participants. It will include both healthy volunteers and patients with systemic amyloidosis.
- What's involved
- The study involves measurements of radiation exposure from enrollment to 8 days after the start of the study.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 8 days after enrollment to measure whole body effective dosimetry.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Phase 1 Study of 99mTc-p5+14 in Healthy Volunteers and Patients With AL or ATTR Systemic Amyloidosis
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jonathan S Wall, PhD · PRINCIPAL_INVESTIGATOR · University of Tennessee Graduate School of Medicine
Who to contact
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What this trial measures
- Whole body effective dosimetry measurementFrom enrollment to the end of study is 8 days
Whole body effective radiation dose assessed from analysis of organ-specific radioactivity uptake in planar and SPECT images.