School Inner City Air Study: HEPA Cleaners for Viral Infections

This study, called the School Inner City Air Study, is looking at whether portable HEPA (High Efficiency Particulate Air) cleaners can help reduce viral infections in elementary school classrooms. Researchers will place either an active classroom HEPA cleaner or a sham classroom HEPA cleaner (which looks the same but doesn't filter air) in classrooms. The main goal is to see if these cleaners reduce how many viruses are in the air and if they lower the number of infections in students, teachers, and their family members. We will measure if viral pathogens (germs that cause illness) are detected in upper respiratory samples after one year. Children aged 6-12 in grades K-5 who attend participating schools and adults aged 21 and older can join. The study is currently unclear on its recruitment status.

Study design
This is an interventional study where classrooms will be randomly assigned to receive either an active or sham HEPA cleaner. It plans to enroll 200 participants.
What's involved
Participants will have longitudinal (over time) classroom air samples and upper respiratory samples collected. They will also complete symptom surveys.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year, as viral pathogen detection in upper respiratory samples is measured at that time point.

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NCT05953233

School Inner City Air Study

Recruiting
NAAges 6–90InterventionalPrevention
Massachusetts General Hospital
~200 participants
Updated 2025-12-11 on ClinicalTrials.gov
What's tested:Active classroom HEPA cleanerSham classroom HEPA cleaner

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Viral pathogen detected in upper respiratory sample
Measured over 1 year
Viral Infection
1 sites across 1 states
Massachusetts1

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Eligibility criteria

Inclusion

Grades K-5 (age 6-12 years)
Attend one of the schools that the study team has permission to obtain classroom/school environmental samples
Have no plans to move schools within the upcoming 12 months
Subject and/or parent guardian must be able to understand and provide informed consent and also willing to participate in the study
Adult (age 21 or older) parent, caretaker, or household member of child participating in this study, or teacher in classroom participating in study
Able to understand and provide informed consent

Exclusion

Contraindication to or inability to participate in home self-collection of nasal swab samples
Severe chronic diseases (e.g. cancer, genetic or congenital disorders interfering with mobility)
Severe neurobehavioral, neurodevelopmental or psychiatric disorders requiring special assistance
Families who do not speak English or Spanish well enough to complete the survey questions, as validated versions in other languages are not available for all of the measures
Contraindication to or inability to participate in home self-collection of nasal swab samples
Severe chronic diseases (e.g. cancer, genetic or congenital disorders interfering with mobility)
Severe neurobehavioral, neurodevelopmental or psychiatric disorders requiring special assistance
Families who do not speak English or Spanish well enough to complete the survey questions, as validated versions in other languages are not available for all of the measures
  • Viral pathogen detected in upper respiratory sample1 year

    Presence/absence of a respiratory virus in upper respiratory sample