This study is looking at factors that affect the success of soft palate surgery for obstructive sleep apnea (OSA). It also explores if medications like acetazolamide and eszopiclone can help treat OSA in people who don't get better after surgery. You might be able to join if you are at least 21 years old, have moderate to severe OSA, and cannot use or tolerate other common treatments like CPAP or oral appliances. The main goal is to see how much your apnea-hypopnea index (a measure of OSA severity) changes 6 months after surgery. The study plans to enroll 150 participants, but its current recruitment status is unclear.

Study design

This is an interventional study that plans to enroll 150 participants. It involves an initial observational phase followed by a randomized crossover study for some participants.

What's involved

You would undergo drug-induced sleep endoscopy and soft palate surgery. Sleep studies (polysomnograms) will be performed before and 6 months after surgery, and with each treatment if you are in the experimental phase.

Compensation

Not stated in the trial record.

Follow-up

Your obstructive sleep apnea severity will be measured 6 months after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.