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Cognitive Enhancement Intervention for Epilepsy

This study is testing a Cognitive Intervention called "L.I.F.E." (Lifestyle Interventions for Epilepsy) to see if it can help people with epilepsy improve their brain health and reduce cognitive difficulties. You might be able to join if you are 18-60 years old, have diagnosed epilepsy, and experience cognitive difficulties. The study involves virtual group sessions led by a neuropsychologist for 12 weeks, followed by 9 months of self-practice. Researchers will compare participants who receive this intervention to those who don't, to see if it improves everyday functioning. The study aims to enroll 170 participants.

Study design
This is a randomized, controlled study comparing a cognitive intervention group to a standard care group. Approximately 170 participants will be enrolled.
What's involved
You would participate in 12 weekly virtual group sessions, followed by 9 months of self-practice, and complete online questionnaires. The total study participation lasts one year.
Compensation
Not stated in the trial record.
Follow-up
Everyday functioning will be measured at 3-12 months from the beginning of the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05954182

Cognitive Enhancement Intervention for Creating a Healthy L.I.F.E (Lifestyle Interventions for Epilepsy)

Active, Not Recruiting
NAAges 18–60InterventionalTreatment
Kayela Arrotta
~170 participants
Updated 2026-07-27 on ClinicalTrials.gov
What's tested:Cognitive Intervention

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Everyday Functioning
Measured over 3-12 months from the beginning of the intervention

Conditions

Epilepsy

Explore related trials

Seizure Disorder

Where it's being run

1 sites across 1 states
Ohio1

Study leadership

  • Kayela Arrotta, PhD · PRINCIPAL_INVESTIGATOR · The Cleveland Clinic

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Potential patients will be identified if they have been, or are scheduled to be seen, either in-person or virtually for a clinical visit within the Cleveland Clinic Epilepsy Center
Adults, aged 18-60 years old, with diagnosed epilepsy
Subjective cognitive difficulties based on patient self-report or objective cognitive deficits as determined by neuropsychological tests
Able to independently provide informed consent
Fluent in English
Reading abilities at or above 8th grade level as determined by the Wide Range Achievement Test- 4th Edition (WRAT-4), Reading subtest
Internet access and the ability to participate in online video streaming
No history of resective or ablative epilepsy surgery
Willing and able to participate in cognitive intervention

Exclusion

Patients with a current diagnosis of non-epileptic or psychogenic seizures
Any patient that has engaged in any form of cognitive rehabilitation/intervention within the last 6 months
Patients currently enrolled in another interventional study for epilepsy at the time of enrollment
Anticipated or scheduled epilepsy surgery within 6 months
Pending litigation related to the cause of epilepsy unless litigation is related to disability application
Undergoing intensive medical treatment for serious or life-threatening illness (e.g., chemotherapy, etc.) that, in the opinion of the investigator, would impact study participation
Serious psychiatric condition that, in the opinion of the investigator, would interfere with participation, such as schizophrenia, active psychosis, active mania, and current suicidal ideation
Currently pregnant or less than 6 weeks postpartum
Significant hearing and/or vision loss that, in the opinion of the investigator would preclude them from participating in remote cognitive testing and engaging in the cognitive intervention
Participants who require an LAR or lack capacity to consent for themselves

What this trial measures

  • Change in Everyday Functioning3-12 months from the beginning of the intervention

    As assessed by the Instrumental Activities of Daily Living-Compensation (IADL-C) questionnaire - Min/Max: 27-216 (higher score means worse outcome)