Surgical Tissue Flap for Glioblastoma

This study is looking at a new surgical technique for people with newly diagnosed glioblastoma (a type of brain cancer). It involves using a piece of your own tissue, called a pedicled temporoparietal fascial (TPF) or pericranial flap, to line the area where the tumor was removed. The goal is to see if this procedure is safe and can help you live longer without the cancer growing (progression-free survival). Researchers will be looking at how long you live without the cancer progressing at 6 months. You might be able to join if you are 18 or older, are having surgery for glioblastoma, and are generally in good health with a life expectancy of at least 6 months.

Study design
This is a single-center study involving 32 participants. It is an open-label study, meaning both you and your doctors will know you are receiving the intervention.
What's involved
You will undergo standard surgery for glioblastoma, followed by the surgical tissue flap procedure. You will have follow-up visits to check for side effects at 72 hours, 7 days, 30 days, 60 days, 120 days, and 180 days.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for side effects and progression-free survival for at least 6 months after the procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05954858

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

Recruiting
NAAges 18+InterventionalTreatment
Northwell Health
~32 participants
Updated 2026-06-01 on ClinicalTrials.gov
What's tested:Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Progression Free Survival (PFS)
Measured over 6 months
Glioma, Malignant
Glioblastoma
Glioblastoma Multiforme
Glioblastoma Multiforme, Adult
High Grade Glioma
GBM
Brain Cancer
1 sites across 1 states
New York1
  • John Boockvar, MD · PRINCIPAL_INVESTIGATOR · Feinstein Institute for Medical Research/Lenox Hill Hospital

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  • Progression Free Survival (PFS)6 months

    PFS is defined as time from surgery until first known disease progression or death from any cause, whichever occurs first.