CAVALIER Trial: Calcium and Vasopressin for Trauma and Hemorrhage

The CAVALIER trial is studying if giving calcium gluconate and vasopressin early can help people who have been severely injured and are at risk of losing a lot of blood (hemorrhagic shock). Researchers want to see if these treatments can improve survival. You might be able to join if you are 18 to 90 years old, have been injured, and have low blood pressure (systolic blood pressure ≤ 90mmHg) and a fast heart rate (HR ≥ 108). The study is looking at how many people are still alive 30 days after treatment. The current status of this study is unclear, but it plans to enroll 1050 participants.

Study design
This is a double-blind, multi-center study, meaning neither you nor your doctors will know if you are receiving the study drugs or a placebo (inactive substance). It is a randomized trial, so participants are assigned to treatment groups by chance. The study plans to enroll 1050 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your health will be followed for 30 days after you are randomized into the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05958342

CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

Recruiting
PHASE2Ages 18–90InterventionalTreatment
Jason Sperry
~1,050 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:Calcium GluconateVasopressinsaline placebo

At a glance

Recruiting sites
16 of 16 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants with 30-day mortality
Measured over from randomization to death or 30 days, whichever comes first
Trauma
Hemorrhage
16 sites across 13 states
Arizona2
Ohio2
Pennsylvania2
Arkansas1
California1
Colorado1
Florida1
Maryland1
  • Jason Sperry, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

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  • Number of participants with 30-day mortalityfrom randomization to death or 30 days, whichever comes first

    all cause mortality within 30 days