CAVALIER Trial: Calcium and Vasopressin for Trauma and Hemorrhage
The CAVALIER trial is studying if giving calcium gluconate and vasopressin early can help people who have been severely injured and are at risk of losing a lot of blood (hemorrhagic shock). Researchers want to see if these treatments can improve survival. You might be able to join if you are 18 to 90 years old, have been injured, and have low blood pressure (systolic blood pressure ≤ 90mmHg) and a fast heart rate (HR ≥ 108). The study is looking at how many people are still alive 30 days after treatment. The current status of this study is unclear, but it plans to enroll 1050 participants.
- Study design
- This is a double-blind, multi-center study, meaning neither you nor your doctors will know if you are receiving the study drugs or a placebo (inactive substance). It is a randomized trial, so participants are assigned to treatment groups by chance. The study plans to enroll 1050 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your health will be followed for 30 days after you are randomized into the study.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
At a glance
Conditions
Where it's being run
16 sites across 13 statesStudy leadership
- Jason Sperry, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Number of participants with 30-day mortalityfrom randomization to death or 30 days, whichever comes first
all cause mortality within 30 days