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Avocados and Type 2 Diabetes Study

This study is looking at whether eating Hass Avocados can help people with Type 2 diabetes manage their blood sugar. Researchers believe that eating one avocado a day might lower fasting blood sugar (how much sugar is in your blood after not eating for a while) compared to eating other fruits with the same amount of calories. You might be able to join if you are between 18 and 65 years old, have Type 2 diabetes, and your HbA1c (a measure of average blood sugar over 2-3 months) is between 5.7% and 11% or your fasting blood sugar is 100 mg/dL or higher. The study aims to enroll 48 participants, but its current status is unclear.

Study design
This interventional study will involve 48 participants. It compares the effects of Hass Avocados to other fruits.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your fasting blood glucose will be measured at Week 5 compared to Week 0.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05958368

Assessing the Value of Avocados on Glycemic Control in Type 2 Diabetes

Recruiting
NAAges 18–65InterventionalTreatment
Pennington Biomedical Research Center
~48 participants
Updated 2025-07-31 on ClinicalTrials.gov
What's tested:AvocadoOther Fruit(s)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Fasting Blood Glucose
Measured over Week 5 - Week 0

Conditions

Diabetes Mellitus, Type 2
Insulin
Fructosamine
C-Reactive Protein
Glucose
Overweight and Obesity

Explore related trials

Type 2 Diabetes Mellitus

Where it's being run

1 sites across 1 states
Louisiana1

Study leadership

  • John W Apolzan, PhD · PRINCIPAL_INVESTIGATOR · Pennington Biomedical Research Center

Who to contact

John W Apolzan, PhD
[email protected]
2257632827
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participant reported diagnosis of Type 2 diabetes
HbA1c between 5.7%-11% (inclusive) and / or fasting blood glucose of ≥ 100 mg/dL
BMI 27-50 kg/m2 (inclusive)
Age range - 18 - 65 years (inclusive)
On stable regimen of all medications (including diabetes) for at least 3 months (brief regimens of medications such as antibiotics, steroids, etc. are permitted)
Willing to follow all requirements of study protocol including blood draws
Under the care of a physician who will be responsible for managing the subject's diabetes
Willing to give release to provide their treating MD with information about the trial
Thyroid disease for which the participant is untreated or has had treatment changed within the last 6 months. History of thyroid disease or current thyroid disease treated with a stable medication regimen for at least 6 months is acceptable
Uncontrolled gastrointestinal disorders including chronic malabsorptive conditions, peptic ulcer disease, Crohn's disease, chronic diarrhea, or active gallbladder disease
Current cancer or cancer treatment, or a history of cancer or cancer treatment within the last 3 years. Persons with successfully resected non-melanoma carcinoma of the skin may be enrolled.
Dementia, psychiatric illness, or substance abuse that may interfere with adherence (e.g., illness that is currently unstable or resistant to first-line therapy; substance abuse in the past year)
Women who are pregnant, lactating, trying to become pregnant or unwilling to use an effective means of birth control
Currently consuming \>14 alcoholic drinks (1 drink = 12 fl oz beer, 4 fl oz wine or 1.5 fl oz liquor) per week and unwilling to stop intake during study participation
Participation in another clinical trial within 30 days prior to enrollment
Any other condition or factor which in the opinion of the study physician or investigator makes it inadvisable for the candidate to participate in the trial

Exclusion

Not willing or unable to consume study foods including avocados
Participation in a weight control program within the past 3 months or weight loss of ≥ 5 kg in the previous 3 months
Taking prescription or OTC weight loss medications within last 4 weeks
History of a surgical procedure for weight loss in last 5 years (e.g. gastroplasty, gastric by-pass, gastrectomy or partial gastrectomy, adjustable banding, gastric sleeve)
History of major surgery within three months of enrollment
Type 1 diabetes, insulin dependent type 2 diabetes, thiazolidinediones (including rosiglitazone and pioglitazone)
Renal insufficiency consisting of potassium over 5.5 (mmol/L) on a non-hemolyzed specimen, or a creatinine over 2.5 mg/dL
Bilirubin over 3 (mg/dL) or an albumin less than 3 (g/dL)
ALT \> 3 (IU/L) times the upper limit of normal (normal range is 7-56)
Evidence of more than 1 severe hypoglycemic event (episode requiring emergency medical services) in the past 12 months, unless the participant's treating physician provides written clearance for participation.
Those on higher doses of diuretics (furosemide 40mg or higher or comparable)
Unstable heart disease (an ongoing workup or treatment for a cardiac symptom such as unstable angina, coronary ischemia)
Presence of implanted cardiac defibrillator

What this trial measures

  • Fasting Blood GlucoseWeek 5 - Week 0

    the primary outcomes are based on within subject concentration change scores