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Study of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

This study is testing a new way to help people who have both Posttraumatic Stress Disorder (PTSD) and Alcohol Use Disorder (AUD). Researchers are comparing a combined therapy called Cognitive Processing Therapy + Relapse Prevention (CPT-RP) with Relapse Prevention (RP) alone. CPT-RP helps with both trauma and alcohol use, while RP focuses mainly on alcohol use. The study aims to see if CPT-RP is better at reducing alcohol use and PTSD symptoms over about 12 weeks. You may be able to join if you are 18 or older, understand English, and have moderate to severe AUD and PTSD. The study plans to enroll 200 participants.

Study design
This interventional study plans to enroll 200 participants. It compares two behavioral therapies: Cognitive Processing Therapy + Relapse Prevention and Relapse Prevention alone.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, changes in alcohol use and PTSD symptoms, are measured through study treatment completion, which is an average of 12 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05959434

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

Recruiting
PHASE2Ages 18+InterventionalTreatment
Texas A&M University
~200 participants
Updated 2026-04-24 on ClinicalTrials.gov
What's tested:Cognitive Processing Therapy + Relapse PreventionRelapse Prevention

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Alcohol Use
Measured over through study treatment completion, an average of 12 weeks
+1 more outcome measured

Conditions

Posttraumatic Stress Disorder
Alcohol Use Disorder

Explore related trials

Alcohol use disorderPost-Traumatic Stress Disorder

Where it's being run

2 sites across 2 states
South Carolina1
Texas1

Study leadership

  • Anka A Vujanovic, Ph.D. · PRINCIPAL_INVESTIGATOR · Texas A&M University
  • Sudie E Back, Ph.D. · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

Anka A Vujanovic, Ph.D.
[email protected]
979-862-6538
Email the study team

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What this trial measures

  • Change in Alcohol Usethrough study treatment completion, an average of 12 weeks

    Composite of alcohol use frequency (percent days drinking) and quantity (drinks per drinking day), as measured by the Timeline Follow-Back

  • Change in Posttraumatic Stress Disorder (PTSD) Symptomsthrough study treatment completion, an average of 12 weeks

    PTSD symptoms as measured by the Clinician Administered PTSD Scale for DSM-5 (CAPS-5)