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Study of Different Nicotine Forms in Vaping

This study is looking at how your body processes different types of nicotine found in e-cigarettes. Researchers will compare 100% (S)-nicotine, 100% (R)-nicotine, and a 50/50 mix of both. They want to understand how each affects nicotine levels over time. You might be able to join if you are a healthy e-cigarette user between 21 and 65 years old, and vape at least 15 days a month. The study aims to enroll 18 participants and is currently unclear on its recruitment status.

Study design
This is a crossover study, meaning participants will try all three types of nicotine. It will involve 18 experienced e-cigarette users.
What's involved
You will spend 8 hours in a hospital research ward for each nicotine type. During this time, you will vape following a set schedule, have a 4-hour break, and then vape as you wish for 90 minutes.
Compensation
Not stated in the trial record.
Follow-up
Your nicotine exposure will be measured for up to 7 hours after vaping.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05962229

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Recruiting
PHASE1Ages 21–65InterventionalBasic science
University of California, San Francisco
~18 participants
Updated 2026-05-14 on ClinicalTrials.gov
What's tested:(S)-Nicotine(R)- nicotineRacemic nicotine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean Nicotine Exposure Over Time
Measured over Up to 7 hours

Conditions

Nicotine Dependence
Nicotine Vaping

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Nicotine Dependence

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Neal Benowitz, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Lisa Lawrence
[email protected]
628-206-4204
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Healthy on the basis of medical history and limited physical examination.
Current regular user of E-Cigarettes (≥ 15 days in the past 30 days)

Exclusion

• Medications
Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).
Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).
Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).
Any stimulant medications (example: Adderall) generally given for ADHD treatment.
Pregnancy (self-reported and urine pregnancy test)
Breastfeeding (determined by self-report)
Women of childbearing potential must be using an acceptable method of contraception
Inability to read and write in English
A known propylene glycol/vegetable glycerin allergy
Uncomfortable with getting blood drawn

What this trial measures

  • Mean Nicotine Exposure Over TimeUp to 7 hours

    Plasma nicotine area under the concentrated time curve (AUC) (ng/ml\*h)