This study is looking at a new way to treat squamous cell carcinoma (a type of cancer) in the oropharynx (part of the throat) that is linked to HPV (human papillomavirus). The goal is to see if a lower dose of radiation therapy, guided by blood tests that check for HPV DNA in your blood, can be as effective as standard treatment but with fewer side effects. This approach aims to reduce the amount of radiation you receive while still controlling the cancer. The study will enroll about 90 participants. Success will be measured by how well the cancer is controlled for up to two years after radiation therapy.

Study design

This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 90 participants.

What's involved

Participants will receive radiation therapy. They will also have regular blood tests (NavDx) to check for HPV DNA, physical exams, and imaging during and after treatment.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for up to 2 years after radiation therapy to assess disease control.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.