High-Intensity Exercise for Vascular and Cognitive Health in Adults with HIV

This study is looking at how different types of exercise might help adults aged 50 and older living with HIV who are experiencing some memory or thinking problems. Researchers want to see if 16 weeks of High-Intensity Interval Training (HIIT) or Continuous Moderate Exercise can improve blood vessel health (vascular function) and thinking abilities (cognitive function). The study will compare these two exercise programs to see which one works better. They also want to understand what makes it easier or harder for people to stick with exercise. To join, you must be 50 or older, have a sedentary lifestyle, have some neurocognitive impairment, and be on stable HIV medication. The study aims to enroll 60 participants in Birmingham, Alabama, but its current recruitment status is unclear.

Study design
This is a single-site, randomized study comparing two exercise programs. It plans to enroll 60 participants.
What's involved
You would participate in a 16-week exercise program, with data collected at the start, after 16 weeks, and three months after the program ends.
Compensation
Not stated in the trial record.
Follow-up
You will have a follow-up visit three months after the exercise intervention is completed.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05965518

High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV

Recruiting
NAAges 50+Interventional
University of Alabama at Birmingham
~60 participants
Updated 2026-08-11 on ClinicalTrials.gov
What's tested:High-Intensity Interval TrainingContinuous Moderate Exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in vascular function
Measured over Baseline, Up to 16 weeks, 3-months Post-Intervention
+1 more outcome measured
HIV
Arterial Stiffness
Cognitive Dysfunction

NCT05965518

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Alabama at Birmingham

    Birmingham, Alabamastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Raymond Jones, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham

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Eligibility criteria

Inclusion

Age 50 years and older
Sedentary lifestyle, defined as \< 150 min/wk moderate physical activity as assessed by CHAMPS questionnaire
Neurocognitive Impairment (as assessed using the BRACE+
Prescribed HIV ART for ≥ 12 months, with no current use of older drugs with established mitochondrial toxicity
Able to speak, read, and write in English
Willingness to participate in all study procedures

Exclusion

Diagnosis of mitochondrial disease
Active substance abuse or factors preventing compliance or safety
Uncontrolled hypertension, defined as resting BP \> 150/90 mmHG
Chronic kidney disease
Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
Acute myocardial infarction identified by medical history and ECG
Pulmonary disease requiring the use of supplemental oxygen
Poorly controlled diabetes
Neuropsychologically Intact
Orthopedic problems that limit ability to perform exercise
Simultaneous participation in another intervention trial
  • Change in vascular functionBaseline, Up to 16 weeks, 3-months Post-Intervention

    Arterial stiffness is a continuous measure of cardiovascular disease risk.

  • Change in cognitive functionBaseline, Up to 16 weeks, 3-months Post-Intervention

    Cognitive function will be measured using BRACE+, a neuropsychological battery