Understanding Fasting's Impact on Hypoglycemia in Type 1 Diabetes

This study is looking at how fasting affects your body's response to low blood sugar (hypoglycemia) if you have type 1 diabetes. Researchers want to see if fasting changes how your body produces hormones like glucagon and glucose from your liver, which are important for raising blood sugar. You might be able to join if you are 18-45 years old, have type 1 diabetes, and are not obese. The study will compare what happens when you fast before experiencing insulin-induced hypoglycemia versus when you eat normally. The main goal is to see if fasting makes it harder for your body to recover from low blood sugar. The study is currently unclear on its recruitment status and plans to enroll 10 participants.

Study design
This is an interventional study, meaning participants will receive specific interventions (fasting or feeding) before experiencing insulin-induced hypoglycemia. It plans to enroll 10 participants.
What's involved
Participants will undergo procedures where they are either fasted or eat normally before insulin is given to induce low blood sugar. Measurements will be taken during these procedures, up to 2.5 hours.
Compensation
Not stated in the trial record.
Follow-up
Measurements of glucagon, hepatic glucose production, and glucose infusion rate will be taken during the procedure, up to 2.5 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05973799

Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes

UNKNOWN
NAAges 18–45InterventionalBasic science
University of Cincinnati
~10 participants
Updated 2024-09-03 on ClinicalTrials.gov
What's tested:FastingFeeding

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Glucagon
Measured over During procedure, up to 2.5 hours
+2 more outcomes measured
Hypoglycemia
Type1diabetes
1 sites across 1 states
Ohio1

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Eligibility criteria

Inclusion

males and females of any race or ethnicity
non-obese (BMI \< or = to 30)
have a diagnosis of type 1 diabetes
C-peptide negative

Exclusion

pregnant women
cigarette smoking
Taking inflammation-targeting steroids (e.g., prednisone).
Taking medications targeting adrenergic signaling (e.g., beta-blockers, bronchodilators).
Hematocrit less than 33%.
Presence of HIV or hepatitis (due to their deleterious effects on the liver).
The presence of cardiovascular or peripheral vascular disease.
The presence of neuropathy, retinopathy or nephropathy.
A detection of the presence of any other disease or condition by one of the study doctors, that would be expected to confound the responses to insulin-induced hypoglycemia or make participation in the study dangerous to the individual.
  • GlucagonDuring procedure, up to 2.5 hours

    From plasma

  • Hepatic glucose productionDuring procedure, up to 2.5 hours

    From plasma

  • Glucose infusion rateDuring procedure, up to 2.5 hours

    Amount of glucose required to maintain glycemia at \~55 mg/dL.