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Understanding Tumor Changes During Radiotherapy for Cervical and Pancreatic Cancer

This study is looking at how tumors change during and after radiation therapy for locally advanced cervical and pancreatic cancer. Researchers will collect tumor samples (biopsies) and blood samples at different times before, during, and after your treatment. They will also use special MRI scans called Diffusion Basis Spectrum Imaging (DBSI) to get detailed pictures of the tumors. The main goal is to understand how the tumor's environment changes over time. You may be able to join if you are at least 18 years old, have locally advanced cervical or pancreatic cancer, and are planning to receive radiation therapy. This study aims to help doctors better understand and treat these cancers in the future.

Study design
This is a prospective longitudinal study, meaning researchers will follow participants over time. It plans to enroll 60 participants.
What's involved
You would have tumor biopsies, blood draws, and MRI scans at several points before, during, and after your radiation therapy. These procedures are linked to your treatment schedule.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for changes in the tumor microenvironment for an estimated 5 years after treatment completion.

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NCT05975593

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

Recruiting
NAAges 18+InterventionalDiagnostic
Washington University School of Medicine
~60 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:Tumor collection via biopsyBlood collectionDiffusion basis spectrum imaging (DBSI) magnetic resonance imaging (MRI)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in tumor microenvironment
Measured over From start of follow-up through completion of follow-up (estimated to be 5 years)

Conditions

Locally Advanced Cervical Carcinoma
Locally Advanced Cervical Cancer
Locally Advanced Pancreas Cancer
Locally Advanced Pancreatic Carcinoma
Locally Advanced Pancreatic Cancer
Cervical Cancer
Pancreas Cancer
Pancreatic Cancer
Cancer of the Cervix
Cancer of the Pancreas

Explore related trials

Cervical CarcinomaPancreatic Carcinoma

Where it's being run

1 sites across 1 states
Missouri1

Study leadership

  • Michael Waters, M.D., Ph.D. · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

Who to contact

Michael Waters, M.D., Ph.D.
[email protected]
314-273-0275
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Confirmation of intent to receive radiotherapy for one of the following diagnoses:
Cervical cancer
Pancreatic cancer
ECOG performance status ≤ 2
At least 18 years old
Able to understand and willing to sign an IRB-approved written informed consent document

Exclusion

Any issue (medical, anatomic, other) that might preclude safe acquisition of biospecimens at the discretion of the treating physician

What this trial measures

  • Changes in tumor microenvironmentFrom start of follow-up through completion of follow-up (estimated to be 5 years)

    Generalized linear mixed effects models will be first used to capture the changes in the longitudinal values of a single assay output over time for a given biospecimen. Random effects will be used to describe the correlation of repeated measures on the same subject over time.