Study of Paclitaxel for Gastric Cancer with Carcinomatosis or Positive Cytology

This study is looking at how well a drug called paclitaxel works when given around the time of surgery (perioperative) for people with gastric adenocarcinoma (stomach cancer) that has spread to the lining of the abdomen (carcinomatosis) or has cancer cells found in fluid samples (positive cytology). Researchers want to see if paclitaxel, given directly into the abdomen (intraperitoneal injection), along with surgery to remove part or all of the stomach, can improve outcomes. You might also receive other medications like dexamethasone, diphenhydramine, and famotidine through a vein. The study will also look at how safe this treatment is. We are enrolling about 30 adults aged 18 and older who have a good enough physical ability (ECOG performance status ≤ 2).

Study design
This is an interventional study with a planned enrollment of 30 participants. It is a Phase II study, meaning it's an early-stage study to see if a new treatment is effective and safe.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for adverse events through study completion, which is an average of 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05977998

A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology

Recruiting
PHASE2Ages 18+InterventionalTreatment
M.D. Anderson Cancer Center
~30 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:PaclitaxelDexamethasoneDiphenhydramineFamotidine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0
Measured over through study completion; an average 1 year.
Gastric Adenocarcinoma
Carcinomatosis

NCT05977998

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • M D Anderson Cancer Center

    Houston, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Brian Badgwell, MD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

Opens a ready-to-send draft in your own email app — review before sending.

  • Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0through study completion; an average 1 year.