Study of Paclitaxel for Gastric Cancer with Carcinomatosis or Positive Cytology
This study is looking at how well a drug called paclitaxel works when given around the time of surgery (perioperative) for people with gastric adenocarcinoma (stomach cancer) that has spread to the lining of the abdomen (carcinomatosis) or has cancer cells found in fluid samples (positive cytology). Researchers want to see if paclitaxel, given directly into the abdomen (intraperitoneal injection), along with surgery to remove part or all of the stomach, can improve outcomes. You might also receive other medications like dexamethasone, diphenhydramine, and famotidine through a vein. The study will also look at how safe this treatment is. We are enrolling about 30 adults aged 18 and older who have a good enough physical ability (ECOG performance status ≤ 2).
- Study design
- This is an interventional study with a planned enrollment of 30 participants. It is a Phase II study, meaning it's an early-stage study to see if a new treatment is effective and safe.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for adverse events through study completion, which is an average of 1 year.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology
At a glance
Conditions
NCT05977998
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
M D Anderson Cancer Center
Houston, Texasstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Brian Badgwell, MD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0through study completion; an average 1 year.