Brain Slice Explants to Predict Drug Response in Brain Tumors

This observational study is looking at whether using brain tissue collected during surgery can help predict how well different treatments might work for central nervous system (CNS) tumors. Researchers will take a small piece of your tumor tissue after it's removed and test it in the lab to see how it responds to various drugs. This approach, called patient-derived explant (PDE), aims to find the most effective therapy for each patient, as CNS tumors can be very different from person to person. The study plans to enroll 50 participants, both children and adults. The main goal is to see how many of these tissue samples can be successfully tested within 28 days.

Study design
This is an observational study with a planned enrollment of 50 participants. It is not a drug trial but focuses on collecting and testing biospecimens.
What's involved
You would provide a biospecimen (tumor tissue) during your surgery. The trial record does not specify any other visits, procedures, or tests for participants.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured up to 28 days after the biospecimen is collected.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05978557

Brain Slice Explants to Predict Drug Response in Brain Tumors

Recruiting
Not specifiedAll AgesObservational
UNC Lineberger Comprehensive Cancer Center
~50 participants
Updated 2025-08-29 on ClinicalTrials.gov
What's tested:Biospecimen collection

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of specimens yielding scores
Measured over Up to 28 days
Central Nervous System Tumor
1 sites across 1 states
North Carolina1
  • Andrew B Satterlee, PhD · PRINCIPAL_INVESTIGATOR · UNC Lineberger Comprehensive Cancer Center

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  • Proportion of specimens yielding scoresUp to 28 days

    The proportion of evaluable specimens yielding patient-derived explant (PDE) drug sensitivity scores. Specimens will be collected during surgery for tumor resection. Excised specimens will be processed to generate PDE-based functional drug screening models. A panel of therapeutics will be chosen for each specimen according to pre-set criteria determined.