Remimazolam for Cataract Surgery and Cognitive Changes

This study is looking at how two different medications, Remimazolam and Midazolam, affect your thinking and memory after cataract surgery. Both medications are given to help you relax during surgery. Researchers want to see if one of these medications leads to fewer changes in your thinking and memory right after surgery and the next day. They will measure this using a test called the Montreal Cognitive Assessment (MoCA). You could be eligible if you are 65 or older, having your first eye cataract surgery, and meet certain health criteria. The study aims to enroll 120 participants. The current status of this study is unclear.

Study design
This study is an interventional study, meaning participants will receive a specific treatment. You will be randomly assigned to receive either Remimazolam or Midazolam during your cataract surgery.
What's involved
You will complete a MoCA test before surgery, after surgery in the recovery room, and again the next day during your follow-up visit. You will also rate your satisfaction with your anesthesia.
Compensation
Not stated in the trial record.
Follow-up
You will be in this study from the day of surgery until your first post-operative visit, which is the following day.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05980117

Remimazolam for Cataract Surgery

Recruiting
PHASE4Ages 65+InterventionalTreatment
University of California, Los Angeles
~120 participants
Updated 2025-03-19 on ClinicalTrials.gov
What's tested:RemimazolamMidazolam

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in MoCA score following surgery in the PACU and post operative day 1.
Measured over Immediately following surgery in the PACU and post operative day 1.
+2 more outcomes measured
Cataract Surgery
Cognitive Impairment
1 sites across 1 states
California1
  • Zhuang Fang, MD · PRINCIPAL_INVESTIGATOR · University of California, Los Angeles

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  • Change in MoCA score following surgery in the PACU and post operative day 1.Immediately following surgery in the PACU and post operative day 1.

    Montreal Cognitive Assessment (MoCA) test. A numerical scale is used for scoring. 18-25 = mild cognitive impairment, 10-17= moderate cognitive impairment and less than 10= severe cognitive impairment

  • Change in MoCA Scores in PACU and the next day between midazolam and remimazolam group.Immediately following surgery in the PACU, and post operative day 1.

    Montreal Cognitive Assessment (MoCA) test. The following ranges may be used to grade severity: A numerical scale is used for scoring. 18-25 = mild cognitive impairment, 10-17= moderate cognitive impairment and less than 10= severe cognitive impairment.

  • Length of postoperative stayPostop day 0 (day of surgery) until discharge from the hospital, usually on postop day 1 (an average of 1 day).

    Duration from the time of admission to readiness for discharge from the PACU. The following ranges may be used to grade severity: