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Prism Adaptation Therapy for Right Brain Stroke Rehabilitation

This study is testing a treatment called Prism Adaptation Therapy (PAT) for people who have spatial neglect after a right brain stroke. Spatial neglect means you have trouble noticing things on your left side, which can make daily tasks like dressing or eating difficult. Researchers want to see if PAT, which involves wearing special glasses for 10 days, can help improve your ability to function independently. They are also working to develop a brain scanning test to identify which patients with spatial neglect would benefit most from PAT. You may be able to join if you are over 18, had a first right brain stroke 1-4 months ago, can sit up, see with both eyes, and point to objects. The study aims to see how much your functional independence improves after 5 weeks.

Study design
This is an interventional study planning to enroll 244 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your functional independence will be measured at 5 weeks after you enroll in the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05983185

Prism Adaptation Therapy (PAT) for Right Brain Stroke Rehabilitation

Recruiting
NAAges 18+InterventionalDiagnostic
VA Office of Research and Development
~244 participants
Updated 2026-04-23 on ClinicalTrials.gov
What's tested:Prism adaptation therapy

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Spatial neglect (SN) type (Aiming SN versus Where SN)
Measured over baseline
+1 more outcome measured

Conditions

Spatial Neglect After Right Brain Stroke

Explore related trials

Spatial NeglectStroke

NCT05983185

Where you'd take part

This study runs at 4 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Atlanta VA Medical and Rehab Center, Decatur, GA

    Decatur, Georgiastudy coordinator listed

    Recruiting

  • Louis Stokes VA Medical Center, Cleveland, OH

    Cleveland, Ohiostudy coordinator listed

    Recruiting

  • VA Central Western Massachusetts Healthcare System, Leeds, MA

    Leeds, Massachusettsstudy coordinator listed

    Recruiting

  • VA Connecticut Healthcare System West Haven Campus, West Haven, CT

    West Haven, Connecticutstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Anna M. Barrett, MD · PRINCIPAL_INVESTIGATOR · VA Central Western Massachusetts Healthcare System, Leeds, MA

Who to contact

Akila Sanjay, BA
[email protected]
(508) 856-0104
Email the study team

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Eligibility criteria

Inclusion

Has had a first right brain stroke \>18 years of age
1-4 months post-diagnosis of right brain stroke
Can sit up, see out of both eyes and point to objects (\>20/50 vision in both eyes)
Can give informed consent to participate

Exclusion

Has been diagnosed with other chronic, disabling neurological disorder (e.g. multiple sclerosis, Alzheimer Disease)
Has had a clinical left brain stroke or has neuroimaging evidence of prior stroke(s) including the presence of more than two lacunes with diameter greater than 15 mm.
Cannot sit up to be tested and receive PAT
Has \<20/50 vision when viewing with both eyes

What this trial measures

  • Spatial neglect (SN) type (Aiming SN versus Where SN)baseline

    This variable is assignment to category defining spatial neglect. This is based on a data collection with computerized line bisection, which generates a profile score. Veterans whose computerized line bisection profile score indicates that they have spatial neglect that primarily affects movement, intention and action have Aiming SN; these Veterans responded best to prism adaptation therapy (PAT) in prior research. Alternately, Veterans may have a profile score consistent with Where SN, affecting perception and action.

  • Functional independence Measure (FIM) improvement trajectory5 weeks after enrollment

    This outcome variable measures how well Veterans can carry out their daily life self-care activities independently on a validated measure, the Functional Independence Measure (FIM).