Combined Thrombectomy for Distal Medium Vessel Occlusion Stroke

This study is looking at whether a procedure called endovascular thrombectomy (using the AXS Catalyst Distal Access Catheter to remove a clot) is better than standard medical care alone for people who have had a specific type of stroke called a distal medium vessel occlusion (DMVO) ischemic stroke. You might be able to join if you are at least 18 years old and have had an acute ischemic stroke where other clot-busting treatments aren't suitable or haven't worked. The study aims to see if endovascular thrombectomy helps improve recovery 90 days after the stroke, as measured by a scale called the modified Rankin Scale. The study plans to enroll 584 participants, but its current status is unclear.

Study design
This is a Phase 3, randomized study where participants will be assigned by chance to either receive endovascular thrombectomy or standard medical care. It is an open-label study, meaning both you and your doctors will know which treatment you are receiving.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your recovery will be assessed 90 days after treatment to see how well you are doing.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05983757

Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe

Recruiting
NAAges 18+InterventionalTreatment
Raul Nogueira
~584 participants
Updated 2026-02-23 on ClinicalTrials.gov
What's tested:Experimental: endovascular thrombectomy in patients who suffer a distal medium vessel occlusionStandard medical management

At a glance

Recruiting sites
3 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Shift in distribution of all levels of the 90-day modified Rankin Scale with levels 5-6 combined (mRS; 0, 1, 2, 3, 4, 5-6) as assessed by structured assessment
Measured over 90-day follow-up
Ischemic Stroke
4 sites across 4 states
Georgia1
Iowa1
Ohio1
Pennsylvania1
  • Raul G Nogueira, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

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  • Shift in distribution of all levels of the 90-day modified Rankin Scale with levels 5-6 combined (mRS; 0, 1, 2, 3, 4, 5-6) as assessed by structured assessment90-day follow-up

    Modified Rankin Scale measurement (mRS): 0=no symptoms, 1= no significant disablity despite symptoms, able to carry out all usual duties. 2= slight disability, unable to carry out all previous activities, but able to look after own affairs without assistance. 3=moderate disability, requiring some help, able to walk without assistance. 4=moderatly severe disability, unable to walk and attend to bodily needs without assistance. 5=severe disability, bedridden, incontinent and requiring total nursing care. 6=dead