Combining Biomarkers and Electronic Risk Scores to Predict AKI

This observational study aims to improve how we predict acute kidney injury (AKI), a sudden decrease in kidney function, in hospitalized patients. Researchers are looking at whether adding information from blood and urine tests (biomarkers) can make a special computer program called ESTOP - AKI 2.0 even better at identifying patients at high risk for severe AKI. The ESTOP - AKI 2.0 program uses information from your electronic health records. The study will enroll 800 adults who are already identified as high-risk by the ESTOP - AKI 2.0 program. The main goal is to see if combining these biomarkers with the electronic risk score can more accurately predict if you will develop Stage 2 AKI within 7 days of joining the study. The current recruitment status is unclear.

Study design
This is an observational study planning to enroll 800 participants. It aims to see if adding biomarkers improves the prediction of AKI when combined with an electronic risk score.
What's involved
If you join, blood and urine samples will be collected over the next 3 days after you are identified as high-risk.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint for developing KDIGO stage 2 AKI is measured within 7 days of enrollment.

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NCT05988658

Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients

Recruiting
Not specifiedAges 18+Observational
University of Chicago
~800 participants
Updated 2025-09-12 on ClinicalTrials.gov
What's tested:ESTOP - AKI 2.0

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Developing KDIGO stage 2 AKI
Measured over Within 7 days of enrollment
Acute Kidney Injury
Biomarkers
2 sites across 2 states
Illinois1
Wisconsin1
  • Jay Koyner, MD · PRINCIPAL_INVESTIGATOR · University of Chicago
  • Matthew Churpek, MD,MPH,PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison

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  • Developing KDIGO stage 2 AKIWithin 7 days of enrollment

    Number of patients developing KDIGO Stage 2 AKI. KDIGO Stage 2 AKI defined as: A double of baseline serum creatinine from baseline OR 12 hours of urine output of less than 0.5ml/kg/hr in those with bladder catheters. If no catheter in place than urine output based AKI cannot be diagnosed