Combining Biomarkers and Electronic Risk Scores to Predict AKI
This observational study aims to improve how we predict acute kidney injury (AKI), a sudden decrease in kidney function, in hospitalized patients. Researchers are looking at whether adding information from blood and urine tests (biomarkers) can make a special computer program called ESTOP - AKI 2.0 even better at identifying patients at high risk for severe AKI. The ESTOP - AKI 2.0 program uses information from your electronic health records. The study will enroll 800 adults who are already identified as high-risk by the ESTOP - AKI 2.0 program. The main goal is to see if combining these biomarkers with the electronic risk score can more accurately predict if you will develop Stage 2 AKI within 7 days of joining the study. The current recruitment status is unclear.
- Study design
- This is an observational study planning to enroll 800 participants. It aims to see if adding biomarkers improves the prediction of AKI when combined with an electronic risk score.
- What's involved
- If you join, blood and urine samples will be collected over the next 3 days after you are identified as high-risk.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint for developing KDIGO stage 2 AKI is measured within 7 days of enrollment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients
At a glance
Conditions
Where it's being run
2 sites across 2 statesStudy leadership
- Jay Koyner, MD · PRINCIPAL_INVESTIGATOR · University of Chicago
- Matthew Churpek, MD,MPH,PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison
Who to contact
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What this trial measures
- Developing KDIGO stage 2 AKIWithin 7 days of enrollment
Number of patients developing KDIGO Stage 2 AKI. KDIGO Stage 2 AKI defined as: A double of baseline serum creatinine from baseline OR 12 hours of urine output of less than 0.5ml/kg/hr in those with bladder catheters. If no catheter in place than urine output based AKI cannot be diagnosed