This pilot study, called CHAP2, is looking at how treating mild high blood pressure (hypertension) during pregnancy might affect the baby's birth weight. If you are pregnant, between 14 and 89 years old, and have blood pressure readings between 130-139/80-89mmHg before 20 weeks of pregnancy, you might be eligible. You would also need to be planning to deliver at UAB Hospital and receiving care at their prenatal clinics. The study will compare two approaches: one group will receive medication (Labetalol or Nifedipine) to keep blood pressure below 130/80mmHg, and the other group will receive usual care, where treatment starts if blood pressure is 140/90mmHg or higher. The main goal is to see if treating blood pressure to a lower target changes the baby's birth weight percentile at delivery. This study aims to gather information for a larger future study.

Study design

This is an interventional pilot study planning to enroll 74 participants. Participants will be randomly assigned to one of two groups: active treatment with Labetalol or Nifedipine, or usual care.

What's involved

At least weekly, a study team member will review participants' blood pressure readings. The study's primary endpoint, neonatal birthweight percentile, is measured at the delivery of the infant.

Compensation

Not stated in the trial record.

Follow-up

Participants are followed until the delivery of the infant, when neonatal birthweight percentile is measured.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.