Comparing Propofol and Inhaled Anesthesia for Surgical Recovery
This study is comparing two common types of general anesthesia: Propofol TIVA (given through an IV) and inhaled anesthesia (breathing in a gas). Researchers want to understand which method leads to a better recovery experience for patients after surgery. They will look at how you feel the day after surgery using a survey called the Quality of Recovery-15 (QOR15) score. This study is for adults aged 18 and older who are having non-heart surgery expected to last at least 60 minutes and require general anesthesia. The study also aims to see if Propofol TIVA has a slightly higher risk of intraoperative awareness (being aware during surgery) compared to inhaled anesthesia. The study plans to include 13,000 patients.
- Study design
- This is a randomized study involving 13,000 patients across multiple centers. Participants will be assigned to receive either Propofol TIVA or inhaled anesthesia.
- What's involved
- Your recovery will be assessed using a survey on the first day after your surgery.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your recovery will be measured on postoperative day 1.
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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
At a glance
Conditions
Where it's being run
20 sites across 15 statesStudy leadership
- Sachin Kheterpal, MD · PRINCIPAL_INVESTIGATOR · University of Michigan
- Michael S Avidan, MBBCh · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine
- Allison Janda, MD · STUDY_DIRECTOR · University of Michigan
- Mark Neuman, MD · STUDY_DIRECTOR · University of Pennsylvania
- Bethany Pennington, PharmD · STUDY_DIRECTOR · Washington University School of Medicine
- Douglas Colquhoun, MBChB · STUDY_DIRECTOR · University of Michigan
Who to contact
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What this trial measures
- Patient Reported Quality of Recovery-15 (QOR15) score on postoperative day 1 after major inpatient surgeryPostoperative day 1
The QOR15 instrument measures quality of recovery with a score of 0 - 150 points where the higher the score the better quality of recovery.
- Patient Reported Quality of Recovery-15 (QOR15) score on postoperative day 1 after minor inpatient surgeryPostoperative day 1
The QOR15 instrument measures quality of recovery with a score of 0 - 150 points where the higher the score the better quality of recovery.
- Patient Reported Quality of Recovery-15 (QOR15) score on postoperative day 1 after outpatient surgeryPostoperative day 1
The QOR15 instrument measures quality of recovery with a score of 0 - 150 points where the higher the score the better quality of recovery.
- Incidence of definite intraoperative awareness with recallPostoperative day 30
The modified Brice questionnaire is used to screen for intraoperative awareness. A positive screen (a patient who reports remembering anything between going to sleep for their surgical procedure and waking up after) on the modified Brice questionnaire is followed by a structured interview. A panel of expert adjudicators determines whether or not this was definite intraoperative awareness.