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Observational Study on Post-Stroke Hemiparesis

This observational study, called TRACTs, is looking at how stroke affects arm movement (hemiparesis). It aims to understand the different parts of arm weakness after a stroke and connect these to changes in the brain's structure and function. Researchers are not testing a specific drug or treatment. Instead, they are observing how stroke impacts movement. You might be able to join if you are 18 to 90 years old, had a stroke more than 6 months ago that caused arm weakness, and can follow simple instructions in English. The main goal is to measure arm movement using the Fugl-Meyer Arm Motor Assessment within two weeks of joining the study. The current recruitment status is unclear, and the study plans to enroll 75 participants.

Study design
This is an observational study with a planned enrollment of 75 participants. It is a single timepoint study, meaning measurements are taken at one specific point in time.
What's involved
You would have research visits at the Providence VA Center for Neurorestoration and Neurotechnology, spanning two to three days. These visits will involve motor outcome measures, magnetic resonance imaging (MRI) of the brain, and transcranial magnetic stimulation (TMS).
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, Fugl-Meyer Arm Motor Assessment, is measured at one cross-sectional timepoint within 2 weeks of research consent. No further follow-up is specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05993221

Deconstructing Post Stroke Hemiparesis

Recruiting
Not specifiedAges 18–90Observational
Providence VA Medical Center
~75 participants
Updated 2025-06-06 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Fugl-Meyer Arm Motor Assessment
Measured over Assessment occurs at one cross-sectional timepoint within 2 weeks of research consent

Conditions

Stroke

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Stroke

NCT05993221

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Providence VA Medical Center

    Providence, Rhode Islandstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Jennifer Hebert, BS
[email protected]
401-273-7100 · ext. 14351
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Eligibility criteria

Inclusion

Diagnosis of a unilateral ischemic stroke occurring \>6 months prior as documented in medical chart
Upper extremity motor impairment as measured by Fugl-Meyer Upper Extremity Assessment ≤60
Ability to follow simple instructions in English

Exclusion

Greater than moderate difficulty using the arm and hand pre-dating the stroke as assessed by the questions adapted from the QuickDASH outcome measure score on any question \>= 3, which measures physical function and symptoms in people with difficulty using the arm and hand.
Visual or auditory disorders resulting in the inability to see or hear, respectively, the stimuli presented as part of research sessions
Inability to maintain a seated position for at least one hour
Standard MRI exclusion (e.g., significant claustrophobia or inability to tolerate loud noises, cardiac pacemaker (unless MRI-safe), implanted device (deep brain stimulation) or metal in the brain, cervical spinal cord, or upper thoracic spinal cord)
Standard (single-pulse) TMS exclusion which include (in addition to those listed for MRI) pregnancy/lactation/planning to become pregnant during the study, seizure disorder, and primary or secondary CNS tumors

What this trial measures

  • Fugl-Meyer Arm Motor AssessmentAssessment occurs at one cross-sectional timepoint within 2 weeks of research consent

    This test provides information about the level of upper extremity motor impairment after stroke. It consists of a 33-item assessment, which provides a global assessment of upper extremity motor impairment. A rater observes 30 voluntary upper extremity motions, two tendon tap responses, and provides an ordinal rating (2 = near normal ability/response, 1 = partial ability, 0 = unable to perform/no response). The Fugl-Meyer Upper Extremity scale has excellent intra-rater reliability (0.99), inter-rater reliability (0.99), test-retest reliability (0.94-0.99), and internal consistency (0.97).