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Immunobiology Blood and Tissue Collection for Head, Neck, Lung, and Gastrointestinal Cancers

This study is collecting blood and tissue samples from people with head and neck, lung, or gastrointestinal cancers. The goal is to understand how different cancer treatments, like those that affect the immune system (immunomodulating treatments), impact the body. Researchers hope to learn why some people respond well to treatments and others don't, and to identify factors that might lead to side effects. This information could help develop better treatments in the future. You might be able to join if you have a confirmed or suspected upper aerodigestive cancer and are considering treatments that affect the immune system. The study is currently collecting samples and plans to enroll about 1250 people.

Study design
This is an observational study, meaning researchers will collect information and samples without giving new treatments. It plans to include about 1250 participants.
What's involved
You would provide biological samples such as tumor tissue, blood, lymph nodes, and other body fluids or cells. The study aims to collect these samples over 10 years.
Compensation
Not stated in the trial record.
Follow-up
Researchers will collect demographic and clinical data for up to 10 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05995821

Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies

Recruiting
Not specifiedAges 18+Observational
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
~1,250 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:Collection of biological specimens

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Demographic and clinical data obtained via chart review
Measured over 10 years
+1 more outcome measured

Conditions

Head and Neck Cancer
Lung Cancer
Gastrointestinal Cancer

Explore related trials

Lung CarcinomaMalignant Digestive System NeoplasmMalignant Head and Neck NeoplasmUpper Aerodigestive Malignancies

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Valsamo Anagnostou, MD, PhD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University
  • Joseph Murray, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

Valsamo Anagnostou, MD, PhD
[email protected]
410-614-8948
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Subjects with a pathologically confirmed or clinically suspected upper aerodigestive malignancy who may be candidates for known or potentially immunomodulating treatments
Ability to understand and willingness to sign a written informed consent document

Exclusion

Patients with known significant contraindications for venipuncture (e.g., hemoglobin \<8.5 g/dL) will be excluded from the blood collection component of the study
Patients with known significant contraindications for biopsy (e.g., severe bleeding diathesis) will be excluded from the tissue biopsy component of the study
Patients with known significant contraindications for bronchoscopy (e.g., airway concerns, significant cardiac disease) will be excluded from the bronchoscopy component of the study
Unable or unwilling to read English and complete forms/questionnaires

What this trial measures

  • Demographic and clinical data obtained via chart review10 years

    This is a clinic based registry of cancer therapy data from participants to be collected over time.

  • Biological specimens obtained from cancer patients10 years

    This is a virtual tissue bank containing biological specimens from participants collected over time.