A Study of PF-07275315 and PF-07264660 for Moderate to Severe Atopic Dermatitis

This study is looking into the safety and effects of two potential new medicines, PF-07275315 and PF-07264660, for people with moderate to severe atopic dermatitis (AD). AD is a long-lasting, itchy red rash. You might be able to join if you are 18 or older, have had AD for at least six months, and your current skin-applied treatments aren't working well. Participants will receive either PF-07275315, PF-07264660, or a placebo (an inactive substance) through injections under the skin. The study aims to see if these medicines can significantly improve your AD symptoms by Week 16.

Study design
This is an interventional study with a planned enrollment of 340 participants. Participants will receive either PF-07275315, PF-07264660, or a placebo.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at Week 16, indicating participants are followed at least until then.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05995964

A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis

Recruiting
PHASE2Ages 18+InterventionalTreatment
Pfizer
~340 participants
Updated 2026-05-04 on ClinicalTrials.gov
What's tested:PF-07275315PF-07264660Placebo

At a glance

Recruiting sites
84 of 98 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The number of participants achieving ≥75% improvement in EAS175 from baseline at week16.
Measured over Week 16
Atopic Dermatitis
98 sites across 54 states
Florida11
California8
Texas5
Ontario5
Arizona4
New York4
Michigan3
Oklahoma3
  • Pfizer CT.gov Call Center · STUDY_DIRECTOR · Pfizer

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  • The number of participants achieving ≥75% improvement in EAS175 from baseline at week16.Week 16

    EASI75 (≥75% improvement from baseline) at Week 16