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Investigating Brain Stimulation for Depression and Epilepsy

This study is looking at how repetitive brain stimulation, specifically Transcranial Magnetic Stimulation (TMS) and intracranial electrodes, affects the brain in people with Major Depressive Disorder or Epilepsy. TMS is a treatment for depression, but researchers want to understand exactly how it changes brain activity to make it work better. You might be able to join if you are 18-65 years old, have epilepsy that requires monitoring, and do not have other major neurological problems. The main goal is to see how brain activity changes after one session of TMS, measured using special electrodes placed inside the brain. The study status is currently unclear.

Study design
This is an interventional study planning to enroll 49 participants. It will involve both non-invasive (TMS) and invasive (intracranial electrodes) brain stimulation.
What's involved
You would receive noninvasive brain stimulation (TMS) both before and after surgery to implant electrodes. Intracranial electrodes would be used for invasive brain stimulation.
Compensation
Not stated in the trial record.
Follow-up
Changes in brain activity will be measured 45 minutes after one TMS session.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05996900

Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans

Recruiting
NAAges 18–65InterventionalBasic science
Stanford University
~49 participants
Updated 2026-03-12 on ClinicalTrials.gov
What's tested:Intracranial electrodesTMS

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
TMS-iEEG change after one TBS session
Measured over 45 minutes

Conditions

Major Depressive Disorder
Epilepsy

Explore related trials

Seizure DisorderUnipolar Depression

Where it's being run

1 sites across 1 states
California1

Who to contact

Jade Truong
[email protected]
(408) 840-3313
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Men and women, ages 18 to 65
Medication-refractory epilepsy requiring phase II monitoring
Must have intellectual capacity to ensure adequate comprehension of the study and potential risks involved in order to provide informed consent
No current or history of major neurological disorders other than epilepsy

Exclusion

Those with a contraindication for MRIs (e.g. implanted metal)
Any unstable medical condition
Neurological or uncontrolled medical disease
Active substance abuse
Currently pregnant or breastfeeding

What this trial measures

  • TMS-iEEG change after one TBS session45 minutes

    Change in evoked response measured after a single TBS session for active and sham, by resting state iEEG (intracranial EEG) and/or sEEG (stereo EEG).