Observational Study on Parathyroid Tumor Clonal Status
This observational study aims to understand the characteristics of parathyroid tumors in people with hyperparathyroidism (a condition where your parathyroid glands make too much parathyroid hormone). Researchers want to find out how often tumors are made of one type of cell (monoclonal) versus many types of cells (polyclonal). They will also look at how this relates to having multiple affected glands. You could be eligible if you are between 18 and 80 years old, male or female, and have been diagnosed with primary, secondary, or tertiary hyperparathyroidism. The study will analyze tumor samples collected during your standard parathyroidectomy surgery. The goal is to compare surgical and lab results with the tumor's cell type over 24 months to better understand these conditions.
- Study design
- This is an observational study planning to enroll 839 participants. It will compare surgical and pathological outcomes to the clonal status of parathyroid tumors.
- What's involved
- You will receive standard of care treatment (parathyroidectomy). De-identified tumor samples from your surgery will be sent for study.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary outcomes of the study will be measured at 24 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Parathyroid Tumor Clonal Status
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Inclusion
Exclusion
What this trial measures
- Primary Endpoint 124 months
1\. Frequency of monoclonal-X versus polyclonal-X parathyroid tumors in patients with hyperparathyroid disorders.
- Primary Endpoint 224 months
2\. To determine the clinicopathologic features of monoclonal-X versus polyclonal-X parathyroid tumors in a prospective multi-center cohort of patients with HPT (PHPT/SHPT/THPT) referred for PTX.
- Primary Endpoint 324 months
Perform a prospective study of biochemical outcomes of PTX in PHPT patients with monoclonal-X and polyclonal-X tumors.