Artificial Tears for Tear Duct Obstruction in Thyroid Cancer Patients

This study is investigating whether using artificial tears (methylcellulose) can prevent a condition called nasolacrimal duct obstruction (NLDO) in people receiving radioactive iodine for thyroid cancer. NLDO is when your tear duct gets blocked, which can happen after radioactive iodine treatment. Researchers believe radioactive iodine might get into tears and cause inflammation, leading to blockages. This study will see if using artificial tears helps reduce this problem. You may be able to join if you are 18 or older, have thyroid cancer, and are receiving a high dose (150 mCi or more) of radioactive iodine therapy. The main goal is to see how many people develop NLDO after two years.

Study design
This is an interventional study planning to enroll 100 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will self-administer artificial tears according to a schedule. The trial record does not specify other visits, procedures, or tests.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for the incidence of NLDO for two years after radiotherapy.

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NCT05999630

Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer

Recruiting
PHASE3Ages 18+InterventionalPrevention
Vanderbilt University Medical Center
~100 participants
Updated 2025-10-28 on ClinicalTrials.gov
What's tested:Artificial Tears Methylcellulose

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of Post-Radiotherapy Nasolacrimal Duct Obstruction (NLDO)
Measured over 2 years
Nasolacrimal Duct Obstruction
Thyroid Cancer
1 sites across 1 states
Tennessee1

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  • Incidence of Post-Radiotherapy Nasolacrimal Duct Obstruction (NLDO)2 years

    The rate of patients that developed NLDO after radioactive iodine therapy in each experimental group as determined by tear duct irrigation by an ophthalmologist.