This study is looking at whether a treatment called accelerated intermittent theta burst stimulation (iTBS), a type of transcranial magnetic stimulation (TMS), can help improve thinking and memory skills in people with schizophrenia or schizoaffective disorder who are already taking clozapine. Researchers want to see if iTBS can boost these brain functions. You might be able to join if you are 18-50 years old, have schizophrenia or schizoaffective disorder, have been on clozapine for at least 4 months, and have tried at least two other antipsychotic medications without success. The study will measure changes in brain activity and how different parts of the brain connect to each other to see if iTBS is effective. The current status of this study is unclear.

Study design

This is an interventional study with a planned enrollment of 30 participants. It is blinded and randomized, meaning neither you nor the researchers will know if you are receiving the active treatment or a sham (inactive) treatment.

What's involved

After an initial evaluation and an MRI scan, you will have two sessions: one with iTBS and one with sham stimulation, each followed by an MRI. The order of these sessions will be random.

Compensation

Not stated in the trial record.

Follow-up

Changes in brain activity and connectivity will be measured at 1 hour after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.