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Peripheral Nerve Stimulation for Chronic Knee Pain

This study is looking at new ways to treat chronic (long-lasting) knee pain. It compares three treatments: a standard steroid injection (triamcinolone and bupivacaine), peripheral nerve stimulation (PNS) therapy combined with a standard steroid injection, and PNS therapy combined with a placebo injection. PNS therapy involves placing a small wire near the nerve causing pain for 60 days, which then sends electrical pulses to block pain signals. The study wants to see how these treatments affect your knee's range of motion and pain levels. You might be able to join if you are between 18 and 85 years old, have chronic knee pain with a pain score of 4 or higher, and are seen at the Pain Management Center at MD Anderson Cancer Center. The main goal is to see if these treatments cause any side effects.

Study design
This is a randomized study with 45 participants. It compares three different treatment approaches for chronic knee pain.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed through study completion, which is an average of 1 year, to monitor for adverse events.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06004882

Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study

Recruiting
NAAges 18+InterventionalTreatment
M.D. Anderson Cancer Center
~45 participants
Updated 2026-08-12 on ClinicalTrials.gov
What's tested:PNS therapyTriamcinoloneBupivacainePlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 4.0
Measured over through study completion; an average of 1 year

Conditions

Peripheral Nerve Stimulation
Genicular Nerves
Chronic Knee Pain

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Pain of joint of knee

NCT06004882

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • M D Anderson Cancer Center

    Houston, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Saba Javed, MD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

Who to contact

Saba Javed, MD
[email protected]
(713) 792-9530
Email the study team

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Eligibility criteria

Inclusion

Patients diagnosed with chronic knee pain (baseline pain score \>=4), seen at Pain Management Center at MD Anderson Cancer Center; if patient has bilateral knee pain, the side with the more severe knee pain will be treated first and counted towards the primary and secondary endpoints
Patients between ages 18-85 years old
Patient signed informed consent

Exclusion

Patients with cognitive dysfunction or without capacity to consent
Patient with recent history (\<6 months) of drug or alcohol abuse
Patients with open skin lesion or undergoing antibiotic therapy for local for systemic infection
Patients with allergies to local anesthesia, steroids, or adhesives
Patients who are on opioids for reasons other than knee pain

What this trial measures

  • Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 4.0through study completion; an average of 1 year