Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
This observational study is looking at how body composition, lifestyle, and diet affect certain immune cells called meta-inflammatory monocytes (MiMos) in teenagers. Researchers believe that adolescents at risk for metabolic diseases like type 2 diabetes might have more active MiMos, which could lead to insulin resistance (when your body doesn't use insulin properly). The study aims to measure glucose (blood sugar) and insulin levels after you drink a sugary drink. You may be able to join if you are between 14 and 18 years old, have reached a mature stage of puberty, and have a normal, overweight, or obese weight, or pre-diabetes. The study is currently recruiting 175 participants.
- Study design
- This is an observational study planning to enroll 175 adolescents. It is not testing any specific intervention or drug.
- What's involved
- This research study collects health-related information and blood samples.
- Compensation
- Not stated in the trial record.
- Follow-up
- Glucose and insulin levels will be measured at 120 minutes and 180 minutes after certain tests.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Kanakadurga Singer, MA, MD · PRINCIPAL_INVESTIGATOR · University of Michigan
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Glucose (OGTT)120 minutes
Plasma Glucose (mg/dL) will be measured prior to, and throughout, an Oral Glucose Tolerance Test (OGTT). Measurements will be taken at baseline (fasting) and 30, 60, 90 and 120 minutes after consumption of glucose dose
- Insulin (OGTT)120 minutes
Plasma Insulin (µU/mL) will be measured prior to, and throughout, an Oral Glucose Tolerance Test (OGTT). Measurements will be taken at baseline (fasting) and 30, 60, 90 and 120 minutes after consumption of glucose dose
- Glucose (MMTT)180 minutes
Plasma Glucose (mg/dL) will be measured prior to, and throughout, a Mixed Meal Tolerance Test (MMTT). Measurements will be taken at baseline (fasting) and 30, 60, 90, 120 and 180 minutes after consumption of high fat shake.
- Insulin (MMTT)180 minutes
Plasma Insulin (µU/mL) will be measured prior to, and throughout, a Mixed Meal Tolerance Test (MMTT). Measurements will be taken at baseline (fasting) and 30, 60, 90, 120 and 180 minutes after consumption of high fat shake.
- Monocyte /macrophage populations by flow cytometry180 minutes
Frequencies by flow cytometry. Measurements will be taken at baseline sample and 180 minutes after consumption of high fat shake