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High-Intensity Exercise for Cognitive Function in Older People with HIV

This study is looking at how high-intensity exercise can help improve thinking and memory (cognitive function) in older people living with HIV. Researchers are comparing two types of exercise: "Phase 1 Gym Exercise HIIT" (High-Intensity Interval Training) and "Phase 1 Gym Exercise CME" (Continuous Moderate Exercise). They are also testing if daily text messages, either personalized coaching ("Phase 2 Home Exercise Coaching Text Messages") or general messages ("Phase 2 Home Exercise Control Text Messages"), can help people stick with exercise long-term. The study aims to enroll 110 participants aged 50 to 80 who have confirmed HIV, a sedentary lifestyle, and are experiencing fatigue. Success will be measured by changes in cognitive function at 4 and 7 months after starting the study. The current status of the study is unclear.

Study design
This interventional study plans to enroll 110 participants. It compares different exercise programs and text message coaching to see their effects.
What's involved
Participants will engage in either gym-based high-intensity interval training or continuous moderate exercise. They will also receive daily text messages and have their cognitive function measured at baseline, 4 months, and 7 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 7 months, with cognitive function measured at 4 months and 7 months after the baseline visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06013579

Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV

Recruiting
NAAges 50–80InterventionalPrevention
University of Alabama at Birmingham
~110 participants
Updated 2025-12-08 on ClinicalTrials.gov
What's tested:Phase 1 Gym Exercise HIITPhase 1 Gym Exercise CMEPhase 2 Home Exercise Coaching Text MessagesPhase 2 Home Exercise Control Text Messages

At a glance

Recruiting sites
2 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cognition
Measured over Baseline visit
+3 more outcomes measured

Conditions

HIV Infections
Cognitive Impairment

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Cognitive DysfunctionHIV Infection

NCT06013579

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Alabama at Birmingham

    Birmingham, Alabamastudy coordinator listed

    Not yet recruiting

  • University of Colorado Denver

    Aurora, Coloradostudy coordinator listed

    Recruiting

  • University of Washington

    Seattle, Washingtonstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Pariya Wheeler, PhD
[email protected]
205-996-0330
Email the study team

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Eligibility criteria

Inclusion

Confirmed HIV
Sedentary lifestyle, defined as self-reported PA that breaks a sweat \<3 days/week, with no regular resistance exercise for 3 months preceding study;
Fatigued (≥2.0 on either of the first two screening items on the HIV-Related Fatigue Scale)
On a current, contemporary ART regimen for \>=12 months;
HIV-1 RNA \<200 copies/mL in the past 12 months (assessed via medical records)
Willing to engage in a supervised exercise program 3 times/week for 4 months
Cell phone or email to accept messages
Weight \<450 lbs
Medical clearance by study healthcare professional

Exclusion

Weight over 450 pounds
Use of sex hormone therapy, if on for ≤3 months (stable doses for \>3 months will be permitted)
Use of other hormone replacement, if on for ≤ 3 months (stable doses \>3 months will be permitted)
Anemia (Hemoglobin ≤9 g/dL for women or ≤10 g/dL for men) due to contribution to fatigue,
Diagnosis of mitochondrial disease,
Active substance abuse or other factors that could prevent compliance or safety with study visits, at the discretion of the site investigator,
Reasons for medical exclusion, as determined by Nurse Practioner:

What this trial measures

  • CognitionBaseline visit

    Cognitive assessment battery test speed of processing, learning, memory, executive functioning, verbal fluency, working memory, motor, subjective cognitive complaints, and everyday functioning.

  • Cognition4 month follow-up visit

    Cognitive assessment battery test speed of processing, learning, memory, executive functioning, verbal fluency, working memory, motor, subjective cognitive complaints, and everyday functioning.

  • Cognition7 month follow-up visit

    Cognitive assessment battery test speed of processing, learning, memory, executive functioning, verbal fluency, working memory, motor, subjective cognitive complaints, and everyday functioning.

  • Cognition12 month follow-up visit

    Cognitive assessment battery tests speed of processing, learning, memory, executive functioning, verbal fluency, working memory, motor, subjective cognitive complaints, and everyday functioning.