Empagliflozin Treatment for Kidney Transplant Recipients

This study is looking at how safe and effective a drug called Empagliflozin is for people who have received a kidney transplant. Empagliflozin is an SGLT2 inhibitor, a type of medicine that has shown benefits for the kidneys and heart in other studies. This trial wants to see if it can help kidney transplant recipients, who often face long-term heart problems. You might be able to join if you are an adult (19 or older) who has had a kidney transplant at least 3 months ago. If you have type 2 diabetes or post-transplant diabetes, your kidney function (eGFR) must be at least 30mL/min. The main goal is to see how many people stop taking Empagliflozin over about two years. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 264 adult participants who have received a kidney transplant.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, discontinuation of Empagliflozin, will be measured at about two years.

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NCT06013865

Empagliflozin Treatment in Kidney Transplant Recipients

Recruiting
PHASE4Ages 19+InterventionalTreatment
VA Office of Research and Development
~264 participants
Updated 2026-04-21 on ClinicalTrials.gov
What's tested:Empagliflozin

At a glance

Recruiting sites
5 of 5 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Discontinuation of Empagliflozin
Measured over about 2 years
Kidney Transplant
Chronic Kidney Disease
5 sites across 5 states
Illinois1
Iowa1
Nebraska1
Pennsylvania1
Tennessee1
  • Roslyn B Mannon, MD · PRINCIPAL_INVESTIGATOR · Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE

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  • Discontinuation of Empagliflozinabout 2 years

    The incidence of therapeutic discontinuation of empagliflozin in the kidney transplant recipient from time of initiation.