Nerve Block + Oral Dexamethasone for Migraine Headache Recurrence

This study is looking at whether a nerve block combined with oral dexamethasone (a steroid medication) can help prevent migraine headaches from returning within 72 hours. You might be able to join if you are between 18 and 85 years old, have migraine headaches that meet specific criteria, and your headache pain significantly improved after a nerve block. The study will compare people who receive two 4mg pills of oral dexamethasone to those who receive two placebo pills (inactive pills). The main goal is to see if taking dexamethasone after a nerve block reduces how often headaches come back within 72-96 hours. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 84 participants. It compares two groups: one receiving oral dexamethasone and one receiving a placebo.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed to measure headache recurrence at 72-96 hours after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06016465

Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?

Recruiting
EARLY_PHASE1Ages 18–85InterventionalTreatment
Texas Tech University Health Sciences Center, El Paso
~84 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:Dexamethasone OralPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Recurrence of headache
Measured over 72-96 hours post treatment
Migraine
1 sites across 1 states
Texas1
  • Susan Watts, PhD. · STUDY_DIRECTOR · Texas Tech University Health Sciences Center, Department of Emergency Medicine
  • Diluma Kariyawasam, MPH · STUDY_DIRECTOR · Texas Tech University Health Sciences Center, El Paso

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Eligibility criteria

Inclusion

Meet ICHD-3 Migraine Headache Criteria
Had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2
Nerve block performed with bupivacaine 0.5%

Exclusion

Head trauma
Suspicion of secondary headache (i.e. stroke, known tumor, glaucoma)
Headache in the setting of viral syndrome
Chronically on steroids
Known allergy to dexamethasone
Unable to reach the patient by phone or text for follow-up
Gestational diabetes or other uncontrolled diabetes
Known to be immunocompromised
  • Recurrence of headache72-96 hours post treatment

    Subjects will be contacted 72 hrs post treatment to determine if migraine headache has recurred