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Blood Flow Regulation and Muscle Fatigue After Stroke Study

This study is looking into why muscles in people who have had a stroke might get tired faster. Researchers want to understand how blood flows to leg muscles during exercise after a stroke. They will use a safe and simple method called ischemic conditioning, where a cuff is inflated on the leg, to see if it can improve blood flow and reduce muscle fatigue. The main goal is to measure how blood flow changes and how that affects muscle fatigue over 3 to 5 years. You might be able to join if you are 18-85 years old, had a stroke at least 6 months ago, and speak English. The study is currently recruiting participants.

Study design
This is an interventional study planning to enroll 40 participants. It includes a randomized, controlled, double-blinded part to test ischemic conditioning.
What's involved
If you are a stroke survivor, you would make six visits to laboratories at Marquette University and the Medical College of Wisconsin. Control participants would make three visits.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, Functional Sympatholysis Magnitude, will be measured at Years 3-5.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06027294

Blood Flow Regulation and Neuromuscular Function Post-Stroke

Recruiting
NAAges 18–85InterventionalTreatment
Medical College of Wisconsin
~40 participants
Updated 2025-09-25 on ClinicalTrials.gov
What's tested:Ischemic Conditioning

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Functional Sympatholysis Magnitude
Measured over Years 3-5

Conditions

Stroke

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Stroke

NCT06027294

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Marquette University

    Milwaukee, Wisconsinstudy coordinator listed

    Recruiting

  • Medical College of Wisconsin

    Milwaukee, Wisconsinstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Matthew Durand, Ph.D.
[email protected]
4149555619
Email the study team

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Eligibility criteria

Inclusion

Be between 18-85 years of age
Able to give informed consent
≥6 months post diagnosis of unilateral cortical or sub-cortical stroke
English speaking

Exclusion

History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg)
Chronic pain syndrome
Low back or hip pain that interferes with lower extremity motor testing
History of head trauma
Comorbid neurological disorder
Peripheral vascular disease
Myocardial infarction in the previous year
Inability to follow 2 step commands
Condition where fatiguing contractions or resisted leg contractions are contraindicated
Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg
Pregnancy or breastfeeding.

What this trial measures

  • Functional Sympatholysis MagnitudeYears 3-5

    Functional sympatholysis will be measured as a change in leg vascular conductance (in ml/min/mmHg) from the exercise control condition to the exercise + cold pressor test condition.