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Comparing Rocuronium and Succinylcholine for Intubation

This study is comparing two different medications, rocuronium and succinylcholine, used during anesthesia to help with intubation (placing a breathing tube). Researchers want to see which medication provides better conditions for intubation, specifically looking at how easy it is to insert the breathing tube, how well the vocal cords are seen and open, and if there's any patient movement or coughing. You might be able to join if you are an adult (18 or older) who needs general anesthesia and intubation, and have a BMI over 30 or a Mallampati class III or IV (which relates to how easily your airway can be viewed). We are looking to enroll 152 participants. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 152 participants to compare two different anesthesia approaches for intubation.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary measurements for this study are taken during the intubation procedure itself, specifically between the insertion of the laryngoscope and the start of ventilation (less than 7 minutes).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06029049

Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine

Recruiting
PHASE4Ages 18+InterventionalTreatment
The University of Texas Health Science Center, Houston
~152 participants
Updated 2024-12-10 on ClinicalTrials.gov
What's tested:Modified Time Principle Induction (MTPI) with rocuroniumRSI succinylcholine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ease of laryngoscopy
Measured over During procedure (Between laryngoscope insertion to onset of ventilation (less than 7 minutes))
+4 more outcomes measured

Conditions

Anesthesia

Explore related trials

Anesthesia Procedure

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Lauren M Nakazawa, MD,MBA · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston

Who to contact

Lauren M Nakazawa, MD,MBA
[email protected]
713-500-6775
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

BMI \> 30kg/m2 or Mallampati class III or IV.
Requiring general anesthesia and endotracheal intubation

Exclusion

Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease(COPD) and asthma.
The American Society of Anesthesiologists (ASA) physical status classification \> III.
Patients requiring awake intubation.
Pregnant women.
Untreated ischemic heart disease.
Patients requiring an induction dose of propofol \< 1 mg/kg.
Allergy to propofol, rocuronium, succinylcholine, or sugammadex.
Patients with renal failure and unknown potassium (K+) level, or patients with K+ level \> 5.0
Personal history of malignant hyperthermia (MH), or family history of MH
Patients with suspected or diagnosed neuromuscular disease, patients with burn injuries

What this trial measures

  • Ease of laryngoscopyDuring procedure (Between laryngoscope insertion to onset of ventilation (less than 7 minutes))

    Ease of laryngoscopy is scored categorically as easy (Jaw relaxed, no resistance to blade during laryngoscopy) , fair (Jaw not fully relaxed, some resistance to blade) or difficult (Poor jaw relaxation, active resistance by patient to laryngoscopy)

  • Position of vocal cordsDuring procedure (Between laryngoscope insertion to onset of ventilation (less than 7 minutes))

    Position of vocal cords is scored categorically as abducted, intermediate or closed

  • Movement of vocal cordsDuring procedure (Between laryngoscope insertion to onset of ventilation (less than 7 minutes))

    Movement of vocal cords is scored categorically as none , moving or closing

  • Number of participants who moved their limbs during intubationDuring procedure (Between laryngoscope insertion to onset of ventilation (less than 7 minutes))

    none, slight or vigorous

  • number of participants who coughed during tracheal intubationDuring procedure (Between laryngoscope insertion to onset of ventilation (less than 7 minutes))

    none, diaphragm or sustained (\>10s)