NCT06029114
MR Elastography of Cognitive Impairment
Enrolling by Invitation
Not specifiedAges 18+ObservationalMayo ClinicInvestigator-initiated
~450 participants
Updated 2026-01-13 on ClinicalTrials.gov
What's tested:Magnetic Resonance Elastography (MRE)
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Shear Stiffness
Measured over Baseline
Conditions
Where it's being run
1 sites across 1 statesMinnesota1
Study leadership
- John Huston, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
In good general health
No Active neurological or psychiatric conditions, if a prior neurological or psychiatric condition was present they must have returned to normal
No cognitive complaints
Normal neurological examination
No psychoactive medications
They may have a chronic medical condition that does not affect cognition
Low Aβ load Pittsburgh compound-B (PiB) ratio \<1.5
In good general health
Memory complaint documented by the patient and collateral source
Normal general cognitive function as determined by measure of general intellectual function and screening including the Short Test of Mental Status
Normal activities of daily living as documented by history and Record of Independent Living
Not demented by DSM-III-R criteria
Do have an objective memory impairment determined by the clinical judgement of the neuropsychologists and neurologists
High Aβ load Pittsburgh compound-B (PiB) ratio ≥1.5
In good general health
Dementia not a result of other medical or psychiatric conditions
Diagnosis of dementia made according to DSM-III-R criteria
Do have objective memory impairment determined by the clinical judgement of the neuropsychologists and neurologists
High Aβ load Pittsburgh compound-B (PiB) ratio ≥1.5
Exclusion
Alzheimer's disease or mild cognitive impairment due to a known genetic mutation
Major depression
History of primary or metastatic intracranial neoplasm, significant head trauma, intra-cerebral hemorrhage, hemispheric stroke
Contradictions to MRI imaging including but not limited to cardiac pacemakers, intraocular or intracranial metal, or other MRI incompatible devices.
Pregnant women. Women of child bearing potential will be given a urine pregnancy test prior the MRI scan. Results will be shared with the participant. If the pregnancy test is positive, the participant will not be included within the study
What this trial measures
- Shear StiffnessBaseline
Brain stiffness measured by the magnetic resonance elastography (MRE) reported in Kilopascal (kPa)