This observational study aims to find older adults with transthyretin cardiac amyloidosis (ATTR-CA) early, when treatments are most effective. Researchers are looking at spinal tissue from people who have had lumbar spinal stenosis (LSS) surgery to see if they have deposits of a protein called transthyretin (TTR). If TTR deposits are found, you might be invited for further evaluation for ATTR-CA, which includes tests like a Tc99-PYP or Tc99-HDMP Scan (a diagnostic imaging test), a genetic test, and heart evaluations. The study hopes to identify how many people with TTR deposits in their spine also have ATTR-CA. To join, you must be at least 50 years old, have had LSS surgery within the last 20 years, and be able to understand and sign the consent form. The current recruitment status is unclear.

Study design

This is a multicenter, prospective cohort observational study with a planned enrollment of 1663 participants. It is not randomized or blinded.

What's involved

If invited for further evaluation, you would undergo nuclear scintigraphy, a TTR genetic test, a clinical evaluation, electrocardiogram, echocardiogram, and complete quality of life questionnaires, likely all on a single day.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint measures the percentage of subjects with TTR amyloid deposits and risk for ATTR cardiac amyloidosis, measured at up to 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.