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LATe Cerclage in High-risk Pregnancies (LATCH)

{ "LATCH Study: Preventing Early Birth in High-Risk Pregnancies", "This study, called LATCH, is looking at whether a procedure called cervical cerclage can help prevent premature birth (preterm birth) in pregnant people who have a short cervix. Cervical cerclage is a stitch placed around the cervix to help keep it closed. You might be able to join if you are 18-50 years old, pregnant with one baby, and have a short cervix (transvaginal ultrasound cervical length of 25mm or less) between 24 and 26 weeks of pregnancy. All participants will also receive or continue using vaginal progesterone 200mg daily. The study will measure how many participants give birth before 37 weeks of pregnancy. The current status of this study is unclear.", "design": "This interventional study plans to enroll 329 participants. If you have a short cervix, you would be randomly assigned to either receive cervical cerclage or not.", "commitments": "If you are in the study, you would either receive a cervical cerclage procedure or not. You would also use vaginal progesterone 200mg daily until 36 weeks of gestation.", "compensation": "Not stated in the trial record.", "follow_up": "The primary outcome, incidence of preterm birth, is measured at delivery.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06036446

LATe Cerclage in High-risk Pregnancies (LATCH)

Recruiting
NAAges 18–50InterventionalTreatment
Thomas Jefferson University
~329 participants
Updated 2026-05-29 on ClinicalTrials.gov
What's tested:Cervical cerclageVaginal Suppository Progesterone

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of preterm birth <37 weeks
Measured over At delivery

Conditions

Premature Birth

Explore related trials

Cervix softPreterm Birth

Where it's being run

2 sites across 2 states
North Carolina1
Pennsylvania1

Study leadership

  • Moti Gulersen, MD, MSc · PRINCIPAL_INVESTIGATOR · Thomas Jefferson University

Who to contact

Moti Gulersen, MD, MSc
[email protected]
215-955-5000
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18-50 years old, pregnant, assigned female at birth
Singleton pregnancy
TVU CL ≤25mm between 24 0/7 - 26 6/7 weeks of gestation

Exclusion

Initial multifetal gestation with subsequent multifetal pregnancy reduction, or selective fetal termination performed \>14 weeks, or cotwin pregnancy loss diagnosed \>14 weeks
Cerclage in situ
Preterm labor, defined as painful regular uterine contractions and change in cervical dilation
PPROM
Active vaginal bleeding
Suspected intraamniotic infection
Major fetal structural abnormality or chromosomal disorder
Placenta previa or accreta
Other contraindication to cerclage placement
Participation in another clinical trial related to preterm birth prevention, cerclage, or progesterone

What this trial measures

  • Incidence of preterm birth <37 weeksAt delivery