Observational Study on Coagulation in Autoimmune Skin Diseases

This study is looking at how blood clotting (coagulation) works in people with autoimmune skin diseases like bullous pemphigoid or lupus. Researchers will collect blood samples from people with active or well-controlled autoimmune skin conditions, as well as from a control group of people without these conditions. They will analyze these samples using standard coagulation tests (like aPTT, INR, ACT) and specialized tests called rotational thromboelastometry (ROTEM) and thrombelastography (TEG). The goal is to compare these results to understand if there are differences in clotting profiles. This information could help guide future studies on how to best manage people with autoimmune skin diseases. You can join if you are 19 years or older and have an immune-mediated skin disease or are a general dermatology patient without certain skin conditions. The study aims to enroll 39 participants.

Study design
This is an observational study, meaning researchers will collect information without giving any new treatments. It plans to include 39 participants.
What's involved
Participants will have a one-time blood draw. The blood samples will be analyzed for various coagulation and inflammatory markers.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, such as Thromboelastography and Activated partial thromboplastin time, will be measured at 2 years.

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NCT06037187

Coagulopathy of Immunodermatologic Diseases

Recruiting
Not specifiedAges 19+Observational
University of Nebraska
~39 participants
Updated 2026-05-12 on ClinicalTrials.gov
What's tested:Blood Draw

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Thromboelastography
Measured over 2 years
+3 more outcomes measured
Autoimmune Bullous Dermatosis
1 sites across 1 states
Nebraska1
  • Erin X Barrett, MD · PRINCIPAL_INVESTIGATOR · University of Nebraska

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  • Thromboelastography2 years

    Thromboelastography is a viscoelastic hemostatic assay that measures the global viscoelastic properties of whole blood clot formation under low shear stress.

  • tPA-challenged Thromboelastography2 years

    Tests patients blood resistance to tPA-mediated clot lysis.

  • Activated partial thromboplastin time2 years

    Activated partial thromboplastin time measures the length of time (in seconds) that it takes for clotting to occur when specific reagents are added to plasma.

  • International normalized ratio2 years

    International Normalized Ratio is a measure of how long it takes your blood to clot.