Observational Study on Coagulation in Autoimmune Skin Diseases
This study is looking at how blood clotting (coagulation) works in people with autoimmune skin diseases like bullous pemphigoid or lupus. Researchers will collect blood samples from people with active or well-controlled autoimmune skin conditions, as well as from a control group of people without these conditions. They will analyze these samples using standard coagulation tests (like aPTT, INR, ACT) and specialized tests called rotational thromboelastometry (ROTEM) and thrombelastography (TEG). The goal is to compare these results to understand if there are differences in clotting profiles. This information could help guide future studies on how to best manage people with autoimmune skin diseases. You can join if you are 19 years or older and have an immune-mediated skin disease or are a general dermatology patient without certain skin conditions. The study aims to enroll 39 participants.
- Study design
- This is an observational study, meaning researchers will collect information without giving any new treatments. It plans to include 39 participants.
- What's involved
- Participants will have a one-time blood draw. The blood samples will be analyzed for various coagulation and inflammatory markers.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints, such as Thromboelastography and Activated partial thromboplastin time, will be measured at 2 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Coagulopathy of Immunodermatologic Diseases
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Erin X Barrett, MD · PRINCIPAL_INVESTIGATOR · University of Nebraska
Who to contact
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What this trial measures
- Thromboelastography2 years
Thromboelastography is a viscoelastic hemostatic assay that measures the global viscoelastic properties of whole blood clot formation under low shear stress.
- tPA-challenged Thromboelastography2 years
Tests patients blood resistance to tPA-mediated clot lysis.
- Activated partial thromboplastin time2 years
Activated partial thromboplastin time measures the length of time (in seconds) that it takes for clotting to occur when specific reagents are added to plasma.
- International normalized ratio2 years
International Normalized Ratio is a measure of how long it takes your blood to clot.