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Optimizing Pain Self-Management in Total Knee Arthroplasty

This study is looking at ways to improve pain after total knee replacement surgery for people with knee osteoarthritis (OA). It will compare two approaches: Savoring Meditation, which teaches you about pain and how to generate positive emotions, and Pain Self-Management and Education, which teaches about the different reasons for chronic pain. The goal is to see if Savoring Meditation can better reduce pain and improve how your brain's reward system works after surgery. You can join if you are 18-85 years old, have a confirmed plan for knee replacement surgery due to osteoarthritis, and are willing to follow the study's schedule. The study will measure pain levels and opioid use from before surgery up to 3 months after.

Study design
This is an interventional study planning to enroll 150 participants. The study type and status are not specified.
What's involved
Participants will attend scheduled sessions and follow study procedures. The duration of these commitments is not fully specified, but primary outcomes are measured up to 3 months post-surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for pain and opioid use from before surgery up to 3 months after surgery.

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NCT06038240

Optimizing Pain Self-Management in Total Knee Arthroplasty

Recruiting
NAAges 18–85InterventionalTreatment
University of Virginia
~150 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:Savoring MeditationPain Self-Management and Education

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Numeric Rating Scale for Clinical Pain
Measured over Baseline to 3 months post-surgery
+1 more outcome measured

Conditions

Osteo Arthritis Knee
Knee Pain Chronic
Surgery

Explore related trials

OsteoarthritisPain of joint of knee

Where it's being run

1 sites across 1 states
Virginia1

Who to contact

Patrick Finan, PhD
[email protected]
4349249514
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18-85 years old.
Have a physician-confirmed treatment plan to undergo unilateral TKA along with physician-confirmed knee osteoarthritis diagnosis.
Willingness and ability to comply with scheduled sessions and study procedures

Exclusion

Member of a vulnerable population including pregnant women, children, prisoners, cognitively impaired, and non-English-speaking subjects.
Current unstable, severe medical comorbidity.
Current severe psychiatric comorbidity (e.g., schizophrenia, psychosis, or other unstable psychiatric disorder).
Current severe alcohol or substance use disorder.
Weekly or more frequent use of opioids in the past 30 days (other than tramadol and/or codeine) for therapeutic or non-therapeutic purposes.
Other surgery of the affected knee in the last 6 months.
Previous TKA.

What this trial measures

  • Numeric Rating Scale for Clinical PainBaseline to 3 months post-surgery

    Average pain intensity on numeric rating scale (range of 0-100; higher scores indicate greater pain), aggregated across Ecological Momentary Assessment observations

  • Opioid UseBaseline to 3-months post-surgery

    Number of opioid prescription refills post-surgery