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NCT06040255

Focal Cerebral Arteriopathy Steroid Trial

Enrolling by Invitation
PHASE4Ages 1–18InterventionalTreatment
University of California, San Francisco
~80 participants
Updated 2026-01-26 on ClinicalTrials.gov
What's tested:methylprednisolone, prednisolone, prednisone

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Focal Cerebral Arteriopathy Severity Score (FCASS)
Measured over Baseline to one month

Conditions

Pediatric Stroke
Arteriopathy
Arterial Ischemic Stroke

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Arterial Ischemic StrokeFocal Cerebral ArteriopathyTransient Ischemic Attack

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Heather J Fullerton, MD, MAS · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

A repeat baseline MRI/MRA can be performed as a research scan within 24 hours of enrollment if needed to meet this requirement.

What this trial measures

  • Change in Focal Cerebral Arteriopathy Severity Score (FCASS)Baseline to one month

    Change in FCASS from baseline to 1 month (1-month delta FCASS) measured centrally on MRA studies (performed on scanners with the same magnet strength). The FCASS is a novel ordinal scale designed and validated for the FOCAS and PASTA trials (Fullerton HJ, Stroke, 2018; Slalova, Eur J Paediatr Neurol, 2020) . The FCASS sums the severity of involvement of each of 5 different arterial segments that can be involved in FCA: (1) supraclinoid ICA (very common), (2) M1 segment of the MCA (very common), (3) M2 branches, (4) A1 segment of the ACA, (5) A2 branches of the ACA. The involvement of the ICA, M1, and A1 are scored on a scale of 0 to 4: 0=no involvement, 1=irregularity or banding without stenosis, 2=less than 50% stenosis, 3= 50% stenosis or greater), 4=complete occlusion. The M2 and A2 are scored: 0=no involvement, 1=irregularity, 3=stenosis, 4=complete occlusion (no option for 2).