Fluoxetine for Recovery After Bodily Trauma
This study is looking at whether taking Fluoxetine (an antidepressant) right after a serious injury can help prevent or lessen mental health problems like PTSD (Post-Traumatic Stress Disorder) and depression. It also aims to see if Fluoxetine can reduce pain, how much pain interferes with daily life, and the need for opioid pain medication. You might be able to join if you are 18 to 85 years old and have been admitted to UF Health for a serious injury like a broken bone needing surgery, a pelvic fracture, or a chest/abdominal injury needing surgery. You also need to have multiple injuries or a certain score on a depression survey. The study is currently unclear about its recruitment status and plans to enroll 200 people. Success will be measured by changes in depression scores over 12 months.
- Study design
- This is a double-blinded, placebo-controlled study, meaning neither you nor your doctors will know if you are receiving Fluoxetine or a placebo (an inactive substance). About 200 people are expected to participate.
- What's involved
- You would take either Fluoxetine (10mg daily for 14 days, then 20mg daily for 9 months) or a placebo by mouth. The study team will monitor you for side effects.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your depression levels will be measured from when you start the study up to 12 months later.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Can Immediate Post-injury Fluoxetine Improve the Recovery Trajectories of Victims in Bodily Trauma?
At a glance
Conditions
NCT06046859
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Florida
Gainesville, Floridano site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Jennifer Hagan, MD · PRINCIPAL_INVESTIGATOR · University of Florida
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Beck Dression Inventory survey, in the post injury period for patients with musculoskeletal trauma.Baseline up to 12 months
BDI-II Beck Depression Inventory: higher score means worse outcome; 0-63.