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Transcranial Alternating Current Stimulation (tACS) for Aphasia After Stroke

This study is looking at how a type of brain stimulation called transcranial alternating current stimulation (tACS) might help people with aphasia (difficulty with language) after a stroke. Researchers want to see if applying HD-tACS (High Definition tACS) during speech therapy can improve language recovery. You might be able to join if you are 18 or older, have aphasia from a left-sided stroke, and your stroke happened at least one month ago. The study will measure improvements in your ability to accurately complete a language task and look at brain activity using fMRI (functional Magnetic Resonance Imaging) after treatment. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 120 participants. It compares HD-tACS with a sham (inactive) HD-tACS during speech therapy.
What's involved
Participants will receive either HD-tACS or sham HD-tACS during speech therapy. Language tasks and fMRI scans will be performed after each 10-day therapy cycle.
Compensation
Not stated in the trial record.
Follow-up
Your language accuracy and brain activity will be measured again 10 weeks after completing the therapy cycle.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06048159

Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke

Recruiting
NAAges 18+InterventionalTreatment
Medical College of Wisconsin
~120 participants
Updated 2026-07-10 on ClinicalTrials.gov
What's tested:HD-tACSSham HD-tACS

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Accuracy on a phonological STM task
Measured over Upon the completion of therapy cycle (a cycle consists of 10 intervention days) and 10 weeks post
+1 more outcome measured

Conditions

Stroke
Aphasia

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AphasiaStroke

NCT06048159

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Medical College of Wisconsin

    Milwaukee, Wisconsinstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Sidney E Schoenrock, MA
[email protected]
414-955-7579
Email the study team

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Eligibility criteria

Inclusion

Diagnosed with left hemisphere stroke/aphasia
Consent date \>= 1 month after stroke onset
Fluent in English
18 years of age or older

Exclusion

Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
Presence of major untreated or unstable psychiatric disease
A chronic medical condition that is not treated or is unstable
The presence of cardiac stimulators or pacemakers
Contraindications to MRI or tACS, e.g. patients with metallic implants, and/or history of skull fractures, pregnancy, skin diseases
History of ongoing or unmanaged seizures
History of dyslexia or other developmental learning disabilities

What this trial measures

  • Accuracy on a phonological STM taskUpon the completion of therapy cycle (a cycle consists of 10 intervention days) and 10 weeks post

    Accuracy changes in a delayed sample-to-match task assessing phonological STM after tACS.

  • fMRI measures of language network activation after tACSUpon the completion of therapy cycle (a cycle consists of 10 intervention days) and 10 weeks post

    Activation in the language network regions involved in phonological STM will be assessed before and after tACS