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Percussive Massage for Muscle Preservation During Leg Immobilization

This study is looking at whether percussive massage can help prevent muscle loss and maintain muscle, blood vessel, and energy-producing cell (mitochondrial) function when a leg is immobilized. All participants will have their left leg immobilized in a brace for 10 days. One group will also receive 30 minutes of percussive massage twice a day during this time. Researchers will measure knee muscle strength, the size of a specific thigh muscle (vastus lateralis cross-sectional area), and how well muscle cells produce energy (skeletal muscle mitochondrial function) before and after the 10-day immobilization period. This study is for people aged 18 to 50 years old, and it is currently unclear if it is recruiting.

Study design
This interventional study plans to enroll 36 participants. It will compare the effects of percussive massage to no massage during leg immobilization.
What's involved
You would have your left leg immobilized for 10 days. You would also have two visits for pre-measurements, which include an MRI, blood flow and vascular function measurements, a muscle biopsy, and muscle strength and endurance tests.
Compensation
Not stated in the trial record.
Follow-up
Your muscle strength, muscle size, and mitochondrial function will be measured immediately after the 10 days of leg immobilization.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06053229

Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization

UNKNOWN
NAAges 18–50InterventionalBasic science
Brigham Young University
~36 participants
Updated 2024-08-13 on ClinicalTrials.gov
What's tested:percussive massageLeg Immobilization

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
knee extensor muscle strength
Measured over Immediately before the onset of leg immobilization and after 10 days of leg immobilization
+2 more outcomes measured

Conditions

Massage Therapy
Muscular Atrophy

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NCT06053229

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Brigham Young University

    Provo, Utahstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Robert D Hyldahl, PhD · PRINCIPAL_INVESTIGATOR · Brigham Young University

Who to contact

Robert D Hyldahl, PhD
[email protected]
8014221237
Email the study team

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Eligibility criteria

Inclusion

18-50 years old (women are pre-menopausal). We will exclude individuals over the age of 50 because the adaptive capability of skeletal muscle fundamentally changes with older age, and the risk from disuse increases. The findings of this study will help determine the risk benefit relationship of conducting a similar study in older individuals.
Stable levels of physical activity for at least 6 months
No history of lower extremity injury that would preclude their ability to perform knee extension exercise

Exclusion

Cigarette or marijuana smoker
Pregnant or planning to become pregnant within next month
Cardiovascular, metabolic disease or cognitive disease (e.g. Alzheimer's or mild cognitive impairment)
Taking prescribed medications (e.g. blood pressure medication) or anti-depressants
Habitual use of any type of massage or vibration on their thigh
Note that subjects who are mentally unable to understand the consenting process and provide informed consent will not be included in this study.

What this trial measures

  • knee extensor muscle strengthImmediately before the onset of leg immobilization and after 10 days of leg immobilization

    Assessed by dynamometry

  • Vastus lateralis cross-sectional areaImmediately before the onset of leg immobilization and after 10 days of leg immobilization

    Assessed by MRI

  • Skeletal muscle mitochondrial functionImmediately before the onset of leg immobilization and after 10 days of leg immobilization

    Assessed in muscle biopsies using in vivo respirometry