Spatial-Motor Stroke-Rehab Study for Spatial Neglect

This study is investigating how two interventions, Prism adaptation therapy (PAT) and electrical stimulation (E-stim), affect people who have had a stroke and experience spatial neglect (difficulty noticing things on one side of their body). PAT involves wearing special prism lenses while making arm movements. Some participants will receive PAT with E-stim, while others will receive PAT with a sham (inactive) stimulator. The study also includes gait training (walking exercises). Researchers want to see how these treatments change visuospatial behavior, brain activity related to movement, and walking ability. They are looking for healthy adults (ages 18-30 and 45-90) and adults aged 40-90 who had a stroke at least three months ago. The study aims to understand if these treatments improve pointing accuracy and brain excitability. The current recruitment status is unclear.

Study design: This is an interventional study with a planned enrollment of 65 participants. It compares two groups receiving Prism adaptation therapy (PAT) – one with electrical stimulation and one with a sham stimulator.
What's involved: Participants will undergo training sessions where their visuospatial pointing behavior, and brain excitability will be measured before and immediately after. After PAT, participants will complete multiple bouts of treadmill or overground walking.
Compensation: Not stated in the trial record.
Follow-up: Measurements are taken at pre-training and immediately after the training session.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Spatial-Motor Stroke-Rehab Study

Recruiting

NAAges 18–90Interventional

Emory University

~65 participants

Updated 2026-05-20 on ClinicalTrials.gov

What's tested:Prism adaptation therapy (PAT) + Electrical stimulation (E-stim)Prism adaptation therapy (PAT) + Sham StimulatorGait Training

At a glance

Recruiting sites

3 of 3 listed sites are recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Change in visuospatial pointing behavior

Measured over Pre-training and immediately after training session

+2 more outcomes measured

Conditions

Spatial Neglect

Stroke

NCT06053320

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

Emory Rehabilitation Hospital
Atlanta, Georgiastudy coordinator listed
Recruiting
Emory University Hospital (EUH)
Atlanta, Georgiastudy coordinator listed
Recruiting
Executive Park
Atlanta, Georgiastudy coordinator listed
Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

Trisha Kesar, PT, PhD · PRINCIPAL_INVESTIGATOR · Emory University
Fisayo Aloba, PT, DPT · PRINCIPAL_INVESTIGATOR · Emory University

Who to contact

Fisayo Aloba, PT, DPT

[email protected]

404-712-5803

Email the study team

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Eligibility criteria

Inclusion

18-30 years

Able-Bodied (healthy without any physical disability or neurological disorder)

45-90 years

Able-Bodied (healthy without any physical disability or neurological disorder)

\>3 months following stroke.

Presence of Aiming SN

Ability to walk \>10m with or without assistive devices.

Unilateral left-sided hemiparesis with gross arm strength of ≤ grade 4/5 on the Medical Research Council Scale

Ability to follow 3-stage commands and provide informed consent.

Exclusion

History or evidence of orthopedic or physical disability

History or evidence of neurological pathology

Pregnancy (female)

Uncontrolled hypertension

Cardiac pacemaker or other implanted electronic system

Presence of skin conditions preventing the electrical stimulation setup

Impaired sensation in the left upper limb.

Bruises or cuts at the stimulation electrode placement site

Concurrent enrollment in rehabilitation or another investigational study.

History or evidence of orthopedic or physical disability interfering with study procedures

History or evidence of neurological pathology or disorder

Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) that may interfere with study procedures

Contraindications to TMS, such as metal implants, medications that can increase cortical excitability, and unexplained dizziness in the past 6 months

History or brainstem strokes

Cerebellar disorders

Impaired sensation in the left upper limb.

History of other neurological disorders

Uncontrolled hypertension

Cardiac pacemaker or other implanted electronic system

Pregnancy (female)

Presence of skin condition

Bruises at the electrode placement site

Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) or other medical conditions that can interfere with study procedures

Contraindications to TMS, such as metal implants in the brain, medications that will increase cortical excitability, etc.

What this trial measures

Change in visuospatial pointing behaviorPre-training and immediately after training session
Measured by the neuropsychological laboratory pointing behavior with the Kessler Foundation Neglect Assessment Process (KF-NAP) tool. Patients are asked to point with their eyes closed towards the center (proprioceptive pointing) and eyes open towards a target (visuo-proprioceptive pointing) on a standing calibrated board unaffected hand). The test is scored by measuring the deviation from 0 (midline). Pre-PAT and post-PAT measures are compared, there is no minimum or maximum score. A more negative score (Pre to Post) means improvement in visuospatial alignment (Improved left spatial neglect) in people post-stroke.
Change in intracortical excitability [paired pulse transcranial Magnetic Stimulation (TMS)]Pre-training and immediately after training session
Primary Motor Cortex (M1) and TMS from the hand muscles (first dorsal interossei) and the ankle (soleus) will be measured using Computer software (Biopac) that will record the muscle's responses to TMS pulses (MEPs) through electromyography (EMG) sensors attached to the skin of the legs and/or arms.
Change in corticospinal excitability (single pulse TMS)Pre-training and immediately after training session
Change in corticospinal excitability measured by the change from baseline in motor evoked potentials (MEP) amplitude responses from the hand muscles (first dorsal interossei) and the ankle (soleus) will be measured using Computer software (Biopac) that will record the muscle's responses to TMS pulses (MEPs) through electromyography (EMG) sensors attached to the skin of the legs and/or arms.

Trialytics