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Understanding Diclofenac Metabolism with Curcumin

This study aims to understand how your body processes diclofenac, a common pain medication, especially focusing on a specific enzyme called UGT2B17. Researchers will also look at how curcumin, a natural supplement, might affect this process. They want to see how diclofenac levels in the blood change over 12 hours in people with different UGT2B17 enzyme activity, both with and without curcumin. This information will help doctors understand how diclofenac works in different people and potentially reduce risks. You may be able to join if you are a healthy adult between 18 and 65 years old and are not taking other medications or supplements that could interfere with the study drugs. The study plans to enroll 30 participants, but its current status is unclear.

Study design
This is an interventional study, meaning participants will receive specific treatments. It plans to enroll 30 healthy volunteers.
What's involved
You would need to abstain from caffeinated beverages and other caffeine-containing products the evening before and morning of the first day of each study arm, and be willing to abstain from other items not specified.
Compensation
Not stated in the trial record.
Follow-up
Diclofenac levels will be measured for 12 hours after administration.

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NCT06053411

Contribution of UGT2B17 to the Pharmacokinetics of Diclofenac

Recruiting
EARLY_PHASE1Ages 18–65InterventionalBasic science
Washington State University
~30 participants
Updated 2026-06-04 on ClinicalTrials.gov
What's tested:Diclofenaccurcumin

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Diclofenac area under the concentration vs. time curve (AUC) in UGT2B17 extensive metabolizers (EMs)
Measured over 0-12 hours
+11 more outcomes measured

Conditions

Interaction

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Washington1

Who to contact

Mary F Paine, RPh, PhD
[email protected]
509-358-7759
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Aged from 18-64 years and healthy
Not taking any medications (prescription and non-prescription) or dietary/herbal supplements known to alter the pharmacokinetics of diclofenac or curcumin
Willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and morning of the first day of each study arm
Willing to abstain from consuming any alcoholic beverages for one day prior to any study day, during the 14-hour inpatient days, and for the outpatient visit(s) following the 14-hour days
Willing to use a secondary method of birth control that does not include the introduction or discontinuance of hormonal-based birth control (such as abstinence, copper IUD, or condoms)
Have the time to participate
Written informed consent (and assent when applicable) obtained from subject or subject's legal representative and ability for the subject to comply with the requirements of the study

Exclusion

Under the age of 18 or over the age of 65 years
Smoke/vape/chew tobacco products
Use cannabis products, including marijuana, hemp, and other THC- or CBD-containing products
Have any current major illness or chronic illness such as (but not limited to) kidney disease, hepatic disease, diabetes mellitus, hypertension, coronary artery disease, chronic obstructive pulmonary disease, cancer, or HIV/AIDS
History of anemia or any other significant hematologic disorder
History of drug or alcohol addiction or major psychiatric illness
Pregnant or nursing or plan to become pregnant within 3 weeks after participation
History of allergy intolerance to diclofenac or curcumin
Taking concomitant medications, both prescription and non-prescription (including dietary supplements/herbal products), known to alter the pharmacokinetics of diclofenac or curcumin
Taking any turmeric spice or curcumin supplement
Presence of a condition or abnormality that, in the opinion of the Investigator, would compromise participant safety or quality of the data
Out-of-range clinical laboratory value that the study physician considers participation in the study a health risk

What this trial measures

  • Diclofenac area under the concentration vs. time curve (AUC) in UGT2B17 extensive metabolizers (EMs)0-12 hours

    Diclofenac AUC in UGT2B17 EMs

  • Diclofenac AUC in poor metabolizers (PMs)0-12 hours

    Diclofenac AUC in UGT2B17 PMs

  • Diclofenac AUC in EMs in the presence of curcumin0-12 hours

    Diclofenac AUC in UGT2B17 EMs in the presence of curcumin

  • Diclofenac maximum concentration (Cmax) in EMs0-12 hours

    Diclofenac Cmax in UGT2B17 EMs

  • Diclofenac Cmax in PMs0-12 hours

    Diclofenac Cmax in UGT2B17 PMs

  • Diclofenac Cmax in EMs in the presence of curcumin0-12 hours

    Diclofenac Cmax in UGT2B17 EMs in the presence of curcumin

  • Diclofenac renal clearance (CLr) in EMs0-12 hours

    Diclofenac CLr in UGT2B17 EMs

  • Diclofenac CLr in PMs0-12 hours

    Diclofenac CLr in UGT2B17 PMs

  • Diclofenac CLr in EMs in the presence of curcumin0-12 hours

    Diclofenac CLr in UGT2B17 EMs in the presence of curcumin

  • Diclofenac half-life (t1/2) in EMs0-12 hours

    Diclofenac t1/2 in UGT2B17 EMs

  • Diclofenac half-life (t1/2) in PMs0-12 hours

    Diclofenac t1/2 in UGT2B17 PMs

  • Diclofenac half-life (t1/2) in EMs in the presence of curcumin0-12 hours

    Diclofenac t1/2 in UGT2B17 EMs in the presence of curcumin